Research On Epidemiology And Resistance To Antibiotics Of Methicillin-rssistant Staphylococcus Aureus (MRSA)

Objective:To study the clinical characteristics of patients with methicillin-resistant Staphylo-coccus aureus (MRSA) infection and drug resistance of MRSA, and Analysis the drug resistance spectrum of MRSA from the clinical specimens specimens and environmental microbiology monitoring specimens, in order to provide a basis for effective preservation measures of MRSA nosocomial infection. Methods:Using the retrospective monitoring methods to investigate and analyze patients’clinical data caused by MRSA in order to master thedistribution, infection risk factors and antibiotics-use; Collecting40cases of infection in patients with MRSA and the corresponding hospital environmental microbial specimens and carry out drug sensitive experiment on the positive samples and analysis the homology. Results:1) In the71patients infected with MRSA, the numble of male is44than female is27, the average is47.32±23.61.the numble of HA-MRSA is54(76.06%) and the rate of HA-MRSA is0.11%, the numble of HA-MRSA is17.2) The community-associated MRSA infections were mainly Cutaneous and mucosal infection, and it is different from hospital-acquired MRSA; The respiratory tract were main infection sites of the community-associated MRSA and hospital-acquired MRSA. There was significant difference in age, the length of days, being in ICU, surging and invasive operation.3) The rate of MRSA nosocomial infection in intensive care ward is higher than in the general ward and they have statistically significant difference (P<0.05); The respiratory tract infection (61.11%) and bloodstream infections (27.78%) are the main infection site in the intensive care ward; The surgical site and skin-soft tissue are the main infection site in the general ward, The proportion of different infection site is different (P<0.05); there are differences in age, disease prognosis, underlying diseases, insertion of the operation and surgical aspects between patients with MRSA nosocomial infection in the intensive care ward and in the general ward (P<0.05).4) Collecting Environment and air, ground crew workers, nursing staff, and many othe kinds of surface, a total of121specimens of cultivated 4strains MRSA, throughspectral analysis showed that drug-resistant bacteria with a high degree of homology. Conclusion:1) The MRSA monitoring should be strengthened on the younger and skin-soft-tissue infection, in order to find and control source of community source of infection the elder, key-department and patients with risk factors patients should be payed attention to the HA-MRSA monitoring and disinfection measures.2) there are differences patients with MRSA nosocomial infection in the intensive care ward and in the general ward, and we should take different emphases measures.3) The environment specimens and the clinical specimens exist homology, there is the hidden trouble of the cross infection in our hospital, we should strengthen MRSA infections surrounding environment of cleaning and disinfection job.