Study Of The Diagnostic Value Of Transrectal Real-time Ultrasonic Elastography(TRTE) In Prostate Cancer (PCa)

Objective:To investigate the value of transrectal real-time ultrasonic elastography (TRTE) for benign prostate hyperplasia (BPH) and prostate cancer (PCa) differential diagnosis and the correlation of TRTE with Gleason scores and clinical stages.Methods:Patients that were doubtful of PCa underwent a conventional TRTE check between October2011and September2012in our hospital. The results of strain ratio (SR) gained from quantitative analysis and elastic scores gained according to Ophir prostate five points-elastic scores were compared and analyzed with pathologic results and clinical stages to investigate the value of TRTE for BPH and PCa differential diagnosis.Results:The area under the receiver operating characteristic curves (ROC curves) of SR max were0.704for differential diagnosis of BPH and PCa (95%CI0.570-0.837, P <0.01), when a cutoff point of16.50was used, SR max had a sensitivity of64.50%and a specificity82.9%; the area under the ROC curves of SR min were0.723for differential diagnosis of BPH and PCa(95%CI0.592-0.853, P<0.01), When a cutoff point of10.76was used, SR min had a sensitivity of61.30%and a specificity85.7%; when a cutoff point of3was used, elastic score had a sensitivity of83.90%and a specificity of65.70%. SR max has a low positive correlation with Gleason scores (r0.322, P=0.038); SR min has a moderately positive correlation with Gleason scores (r=0.413, P=0.021); SR max and SR min has no significant statistically significant correlation with clinical stages (r=-0.114, P=0.543; r=-0.060, P=0.748). Elastic score has a moderately positive correlation with Gleason scores and clinical stages respectively (r=0.450, P=0.011; r=0.595,P<0.001)Conclusions:TRTE is valuable for differential diagnosis of BPH and PCa, and it has a certain degree of correlation with Gleason scores and clinical stages.