| Objectives:To observe the effect of recombinant human epidermal growth factor gel on postoperative canal wall down tympanoplasty cavity epithelization and discuss the mechanisms of its effects.Methods:Fifty-six cases (56ears) with cholesteatoma undergone radical mastoidectomy+tympanoplasty+conchaplasty in the department of ENT in the first affiliated hospital of Kunming Medical University were included. Two weeks after operation, cavity gauze were extracted。 All the cases were randomized into two groups, experimental group (28ears) and control group (28ears).The postoperative cavity of experimental group were dressed with hydrocortisone chloramphenicol ear drops and rhEGF gel。 The control group were dressed with hydrocortisone chloramphenicol ear drops。 The information including cavity secretion, granulation, epithelialization, local and systemic side-effects were observed during treatment。 The time of epithelialization were carried on statistics processing.Results:The epithelization time of postoperative cavity in experimental group and the control group were an average of61±3.15and90±7.73days respectively。 The difference was statistically significant (P<0.05)。 Compared with the control group, cavity inflammatory exudation, bleeding, pain were less in the dressing process in experimental group。 The epithelium of the cavity of experimental group was smooth after epithelialization, granulation and scar were little, subepithelial capillary was clear. Side effects and adverse reaction of the two groups were not obvious in the course of treatment and follow-up.Conclusion:Recombinant human epidermal growth factor gel can reduce the surgical cavity inflammatory exudation, reduce the bleeding and pain in dressing process, accelerate the epithelialization of open tympanoplasty cavity, shorten epithelization time, reduce the formation of granulation and scar, with no obvious side effect. |
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