Gestational Trophoblastic Tumor With Liver Metastases:Case Report And Review Of The Literature

Objective To investigate the risk factors,clinical characteristics,treatment and prognosis of the gestational trophoblastic tumor with liver metastases.Materials and methods The retrospective analysis was carried out to evaluate the clinical data of2patients with GTT with liver metastases treated in Women’s Hospital, ZheJiang University School of Medicine, from2000to2009. And review the literature to discuss the features.Results Case one:A54years old female finding the HCG elevated after5years of partial hydatidiform mole pregnancy. The imaging shows lesions in liver, lung and brain. The patient was treated by EP/EMA for5courses. And the disease relapsed after1+year; Case two:A26years old female, she was diagnosed as gestational trophoblastic tumor after an abortion1years ago and had irregular treatment of chemotherapy.1+years after primary treatment she was admitted in our hospital because of headache, chest tightness and consciousness. Imaging shows lesions in both liver and brain. She received4courses of EP. She didn’t continue the remain courses for financial reasons. Conclusions The incidence of GTN with liver metastases has been decreased with the constantly awareness of gestational trophoblastic and the discovery of new efficient chemotherapy. Secondary to non-molar pregnancy, long incubation period, irregular chemotherapy and resistant to chemotherapy are the characteristics of GTN with liver metastases. Since liver metastases always companied with metastases to other organs, the patients are assigned to the high risk group. Standardized Multiagent chemotherapy is still the first choice for liver metastases.After all the treatment of liver metastases should be individualized.