| Gastric cancer of the digestive system of the most common malignant tumor, ulcer cancer). Gastric cancer curative effect and the disease diagnosis and treatment and sooner or later period method and means is closely related to the treatment of early gastric cancer after enough after more than90%patients can live above5years or cure, and very advanced gastric cancer patients after treatment,5years survival rate less than5%. Therefore, early detection is to improve the curative effect, improve the survival rate of the key.Gastric cancer in addition to early detection of early treatment to affect the survival and treatment effect of the outside factors, the transfer of gastric cancer and infiltrating is also an important factor affect the prognosis of gastric cancer, as solid tumors, the transfer or infiltration depends on the role of blood vessels, at present a lot of research suggests and angiogenesis factors related with the prognosis of gastric cancer or clinical pathological characteristics are related, Ryan by immunohistochemical studies suggest in normal tissue or benign tumor, HIF-1a in low expression state, and in malignant tumor, HIF-1a in high expression state, in a transfer of malignant tumor, HIF-1a expression in a higher level; Extracellular matrix as tumor cells infiltrating transfer or the natural physiological barrier, in the development process of tumor also play an important role; MaLiJuan [2] studies suggest matrix metalloproteinase-2(MMP-2) in gastric cancer in a large number of expression, matrix metalloproteinase-2biodegradable extracellular matrix, and in its infiltration and transfer plays an important role. Vascular endothelial growth factor (VEGF) to promote the growth of blood vessels and lymphatic important factor, a lot of research at home and abroad are suggesting that its and tumor growth and metastasis closely related; Depend on ammonia acyl oxidase (LOX) and extracellular matrix is closely related to the mature, the domestic and foreign related research suggests it with the transfer of malignant tumor and infiltrating related [3]. At home and abroad and have research suggests VEGF and LOX happened in gastric cancer and the effect, but between them the expression of gastric cancer in the pertinence between research yet, so in gastric cancer invasion and metastasis of molecular biology, further research is necessary to further molecular biology for clinical treatment of gastric cancer and can predict the prognosis of patients with gastric cancer provide certain molecular biological basis.Objective:To study the LOX and VEGF in gastric cancer and cancer tissue adjacent to the expression, to determine the relationship between the gastric cancer happen; Through the analysis of the gastric cancer associated with lymph node metastasis of lymph node metastasis and the expression to determine the relationship between the development of gastric cancer, Through the analysis in different infiltration depth (T1T2and T3T4) to judge the expression situation with the gastric cancer development, the relationship between Through the analysis of the relationship between them to judge this both in gastric cancer happening and development of joint action.Methods:The data of2011September2013-January in jingzhou city was a hospital, huangshi a hospital, and the same central hospital three hospitals do surgical resection of fresh gastric cancer and the corresponding carcinoma side organization (distance gastric cancer tissue5cm) in65patients, the Western-Blot method detection organization of LOX, VEGF protein in gastric cancer and cancer tissue adjacent to the expression, access to medical records collect case material, and then use the relevant statistical methods of statistical analysis, the Spearman rank correlation analysis method and VEGF LOX in gastric cancer in the relationship between expression.Results:①LOX relative expression in65cases of gastric cancer was0.4178±0.1135, the relative expression level in adjacent tissues to0.2174±0.1524LOX expression level in gastric cancer tissues was significantly higher than in adjacent group, the difference was statisticallythe relative expression level of significance (P <0.05)②VEGF in65cases of gastric carcinoma0.4793±0.1019, adjacent tissues0.2116±0.1146, the level of VEGF expression in the gastric cancer group was significantly higher than in adjacent group, a statistically significant difference(P <0.05)③relative expression levels of LOX in gastric cancer with lymph node metastasis was0.6827±0.1987, the relative expression level in gastric cancer without lymph node metastasis0.4235±0.1763, associated with lymph node metastasis in gastric cancer LOX expression levels were significantlyhigher than that without lymph node metastasis of gastric cancer, the difference was statistically significant (P <0.05)④VEGF in gastric cancer with lymph node metastasis in the relative expression level to0.6769±0.1659in gastric cancer without lymph node metastasis in the relative expression level of.4128±0.1471, VEGF expression level of gastric cancer with lymph node metastasis was significantly higher than that without lymph node metastasis of gastric cancer, a statistically significant difference (P<0.05)⑤of LOX relative expression levels of in T3T4gastric cancer in.6003±0.1279of gastric cancer in T1T2in the relative expression level0.4278±0.1437, the T3T4gastric LOX expression levels were significantly higher than the T1T2gastric cancer, a statistically significant difference (P<0.05)⑥VEGF T3T4gastric cancer, the relative expression level of.6975±0.1639in TlT2relative expression level in gastric as0.4263±0.1128the T3T4gastric VEGF expression levels were significantly higher than the T1T2of gastric cancer, a statistically significant difference (P<0.05).⑦in65cases of gastric carcinoma, LOX and VEGF expression levelsa positive correlation (r=0.735, P <0.05), with lymph node metastasis in gastric carcinoma, LOX and VEGF expression levels also showed a positive correlation (r=0.914, P<0.05).Conclusion:In gastric cancer tissue, LOX and VEGF expression level is obviously higher than that of the carcinoma side organization, with a statistical significance; In the associated with lymph node metastasis of gastric cancer tissue, LOX and VEGF expression level obviously is higher than without lymph node metastasis of gastric cancer organizations; T3T4in gastric cancer LOX and VEGF expression level obviously is higher than T1T2stomach; In gastric cancer tissue and associated with lymph node metastasis of gastric cancer tissues, the relationship between LOX and VEGF is proportional. LOX and VEGF in gastric cancer happening and development plays an important role in the occurrence of gastric cancer in the process of the development of LOX and VEGF the synergies between the role. |
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