Analysis On The Correlation Among FENO, Lung Function And Zheng Differentiation-classification By Traditional Chinese Medicine And So On In COPD Patients

Objective:To investigate the correlation among fraction of expired nitric oxide(FENO) value, lung function and dialectical typing by traditional Chinese medicine and soon in chronic obstructive pulmonary disease (COPD) patients and to confirm the airwayinflammation degrees in COPD patients. Methods:70COPD in-hospital patients agedbetween48and89were selected. The general data (name, gender, age, nationality, bodyheight, body weight and BMI), personal history (history of smoking) and past history(history of asthma and the seizure frequency in each year) were collected. The patientswere differentiated and classified based on Guidance to diagnosis and treatment of chronicobstructive pulmonary diseases by traditional Chinese medicine. The present pathogeneticconditions were evaluated, and mMRC and CAT rating scales were filled in. FENO valueswere determined by a Swedish NIOX nitric oxide determinator, the FENO values wererecorded, and then the pulmonary ventilation functions were determined by GermanMS-PFT lung function test system, the FEV1%and FEV1/FVC%values were recorded,and the lung functions were classified based on the severities.Results:(1)The averageFENO value in the70COPD patients was(26.416.64)ppb, the minimum was7.1ppb,and the maximum was99.6ppb;(2)The difference in FENO value among different agegroups was statistically significant(P=0.037), and FENO value was decreased followingthe increase of age;(3)The difference in FENO value among different BMI groups wasstatistically insignificant(P=0.516), but FENO value was decreased following the increaseof BMI;(4)The difference in FENO value among groups with different lung functionclasses was statistically significant(P=0.047), and FENO value was decreased followingthe decrease of lung function;(5)FENO value was negatively-correlated with age(γ=-0.111,P=0.047), BMI(γ=-0.098, P=0.042) and FEV1/FVC%(γ=-0.002, P=0.044), namely, FENO value was decreased following the increases of age and BMI and the decrease of lungfunction; and the correlation with gender, body height, body weight and FEV1%wasinsignificant(P>0.05);(6)The types of syndrome in70COPD patients classified bytraditional Chinese medicine and ascendingly sorted based on the incidence were:exogenous cold-evil and internalization, insufficiency of QI of the lung and kidney,pulmonary stagnation of phlegm, phlegm-heat obstructing in the lung, lung-kidney qi-yinasthenia, asthenia of pulmonosplenic qi, lung-qi deficiency, and attack of wind-cold on thelung;(7)The difference in FENO value among groups with different types of syndromeclassified by traditional Chinese medicine was statistically insignificant(P=0.480);(8)Thedifferences in FENO value between each pair of groups with different types of syndromeclassified by traditional Chinese medicine were statistically insignificant(P>0.05).Conclusion: FENO determination has somewhat significances for confirming the airwayinflammation degree in COPD patients.