Association Of IKKi Protein Expression With Clinical Pathological Feature In Hepatitis B Cirrhosis Related HCC

Objective: To evaluate the association of IKKi protein expression of NF-κB signalpath with clinical pathological feature in cirrhosis related HCC.Methods: Cirrhosis of the tumor-adjacent liver tissue in the same case as a comparison, todetect IKKi expression in66cases of hepatitis B cirrhosis related HCC byimmunohistochemistry, collect the clinical pathological material and analysis of theassociation of IKKi expression with clinical pathological feature in HCC.Results:1) IKKi expression level is obviously different between hepatocellular carcinomaand tumor-adjacent cirrhosis tissue (P=0.016), and IKKi expression level intumor-adjacent cirrhosis tissue is stronger than the hepatocellular carcinoma.2) Theexpression level of IKKi in hepatocellular carcinoma were positively correlated withtumor differentiation, which means the lower of expression level of IKKi is the poorer ofHCC differentiation(P=0.019, r=0.278). And the expression level of IKKi inhepatocellular carcinoma were negatively correlated with tumor size,which means thelower expression level of IKKi is the bigger of HCC (P=0.011, r=-0.311).3) Theexpression level of IKKi in hepatocellular carcinoma were positively correlated withage(P=0.034, r=0.261), Child-Pugh classification (P=0.046, r=0.246)and familyhistory(P=0.017, r=0.292) of hepatitis B; the IKKi expression level in tumor-adjacentcirrhosis tissue were negatively correlated with ALT(P=0.031, r=-0.266), AST（P=0.000,r=-0.436），and were positively correlated with ascites.Conclusion:The higher lever of IKKi in hepatocellular carcinoma imply IKKi mayprevent tumor formation in hepatitis B cirrhosis of the liver-hepatocellular carcinoma,may become a new standard of judging the development and prognosis of HCC.