The Value Of PWI To Predict The Outcome Of Posterior Circulation Infarcts

Objective: To explore the value of abnormal volume of mean transition time(VMTT),cerebral blood flow(VCBF), volume of Ischemic penumbra(VIP), ratio of MTT，nationalinstitutes of health stroke scale（NIHSS）, several Perfusion Weighted Imaging(PWI)parameters of the study, to predict the outcome of posterior circulation infarcts. Methods:82Patients(male60, female22.) with acute posterior circulation infarcts (＜72h) fromMarch2012to January2013who must had MRI and NIHSS within72hours of symptomonset and before treatment (＜72hours after symptom onset),1-month,6-monthsfollow-up with modified Rankin scale(mRS) were evaluated. The Average age61±11.3(35-85). Acute DWI and MTT、CBF、CBV lesion volumes and parameter of MTTand baseline NIHSS scores were calculated. rMTT=parameter of abnormal MTT/parameter of normal MTT. Clinical outcomes were considered good if the modifiedRankin Scale was0to2.To Analysis the Correlation between Observed variables andmodified Rankin Scale of1-month(mRS30d)、3-months and6-month(mRS180d).Results:The55of82(61%) patients with good outcomes and2cases were lost. Age, Smoke andWine, Hypertension, Diabetes, Coronary heart disease had no statistical differencebetween two group.(p＞0.05). rMTT、VMTT、NIHSS between two group have statisticaldifference (p＜0.05).The result of Logistic Regression Analysis show that age, smoke,rMTT, DWI, and NIHSS have significant correlation(p＜0.05).. Receiver operatingcharacteristic curves for rMTT relative to3-month outcome had the largest areas under thecurve. Conclusion: rMTT most relevant for the prognosis of outcome.DWI, rMTT andNIHSS batter than others to predict the outcome of posterior circulation infarcts. NIHSSScore early prognosis of the posterior circulation is obvious. For an assessment of thelong-term prognosis is poor.