The Change And Significance Of Serum VEGF In The Han And Uighur Patients With Local Advanced Cervical Cancer Before And After Treatment

Objective：To investigate advanced cervical cancer patients with concurrentchemotherapy and radiotherapy content of serum vascular endothelial growth factor(VEGF) and its clinical significance. Methods：Using enzyme-linked immunosorbentassay (ELISA) to detect the levels of VEGF121cases of concurrent chemotherapy andradiotherapy of patients with cervical cancer II b-IV a serum, and analyzed with clinicalpathological features, treatment and prognosis. Results：The median serum VEGF levelsas786.12pg/ml (52.91-2210.78pg/ml) content in the age＜51years of age (P＝0.015),III IV a-a (P＝0.001), lymph node metastasis at diagnosis (P＜0.001) and tumor size(diameter>4cm)(P＜0.001) were significantly increased, and by Logistic regressionanalysis for predicting earlier radiotherapy and chemotherapy after curative independentrisk factor. Univariate analysis showed age＜51(P＝0.014), poor differentiation of type(P＝0.013), stage (P＜0.001), tumor volume (diameter＞4cm)(P＜0.001), lymph nodemetastasis at diagnosis (P＝0.005) and pretreatment serum VEGF≥786.12pg/ml (P＜0.001), progression-free survival of influencing factors, multivariate analysis found thatadvanced stage (P＝0.002) and serum VEGF≥786.12pg/ml (P＜0.001),progression-free survival of patients with advanced cervical cancer, a short independentrisk factor. Conclusion：Detection of late the level of VEGF levels in the serum ofpatients with cervical cancer may be able to predict treatment outcome and prognosticevaluation indicators, provide clues for the formulation of individualized treatment plan.