Clinical Analysis Of Salvage Chemotherapy In 71 Cases Of Recurrent And Progressing Sequentially Ovarian Carcinoma

Objiection:To evaluate the curative effect of second-line and salvage chemotherapy in recurrent and progressing sequentially ovarian carcinoma in the near future and the influence of their effects.Methods:Clinical data in 71 cases of ovarian carcinoma,who accepted second-line chemotherapy in our hospital from January 2001 to December 2006, was analyzed retrospectively.Among them,20 patients received salvage chemotherapy with Cisplatin,Ifosfamide and Etoposide,41 patients with Paclitaxel and platinum category and 10 patients with Topotecan-Cisplatin.Results:Tow main reasons why 71 patients accepted second-line chemotherapy are the recurrence and the sequential progress of ovarian carcinoma.The total response rate was 71.83%.The curative effects were same among three specific chemotherapy projects,between platium-sensitivity and platinum-resistence,among three specific chemotherapy projects in platium-sensitivity or platinum-resistence(P＞0.05).The medullary restraint was not different among three projects(P＞0.05).The distinction was in the curative effects between accepting secondary cytoreductive surgery(SCRS) and unaccepting SCRS(P＜0.05).Conclusion: Second-line and salvage chemotherapy takes some effects in Recurrent and Progress sequentially ovarian carcinoma.There is not best among second-line chemotherapy.And that the measure of SCRS could improve the curative effect of second-line chemotherapy.