Analysis Of The Related Factors And The Maternal And Fetal Outcomes In Pre-eclampsia Women With Abnormal Glucose Metabolism During Pregnancy

Objective:To explore the related risk factors and the maternal and fetal outcomes inpreeclampsia women with abnormal glucose metabolism during pregnancy.Methods:Aretrospective study was conducted on575pregnant women with abnormal glucosemetabolism during January2009-may2012,all women gestational weeks were more than28weeks and delivered in our hospital. All women were divided into two groups:groupⅠ included121women withpreeclampsia;groupⅡ were454women without preecl-ampsia.Results:1The incidence of abnormal glucose metabolism with preeclampsia wom-en was21.04%.in these abnormal glucose metabolism with pre-eclampsia women,theincidence of gestational diabetes mellitus with pre-eclampsia women was significantlyhigher than that of gestational impaired glucose tolerance with pre-eclampsia women(15.13%vs5.93%,P＜0.05).During the same period,there were1046women got preeclamp-sia(5.1%),the incidence of abnormal glucose metabolism with pre-eclampsia women wassignificantly higher than that of women who got pre-eclampsia (21.04%vs5.1%,P＜0.01).2Single-factor Logistic regression analysis results showed that no difference was shownbetween the two groups in average age,pregnancy weight gain, race and gravidity(P＞0.05).The family history of hypertension,family history of diabetes, prepregnant body massindex(BMI),parity in group Ⅰ was significantly higher than that of group Ⅱ(P＜0.01).M-ultivariate logistic regression analysis results showed that family history of hypertensionand prepregnant (BMI)≥25kg/m2were the independent risk factors in preeclampsiawomen with abnormal glucose metabolism during pregnancy.3Analysis of the maternaland fetal outcomes:The incidence of polyhydroamnios,preterm birth, postpartumhemorrhage,intra-uterine death in group Ⅰ was significantly higher than that of groupⅡ (9.9%vs4.6%,28.1%vs4.8%,9.1%vs4.4%and5.0%vs1.1%,P＜0.01orP＜0.05),no differen-ce was shown between the two groups in the rate of distress,premature rupture ofmembranes (P＞0.05)The incidence of neonatal asphyxia,neonatal hypoglycemia,small orgestational age,hyperbilirubinemia,intracranial hemorrhage,perinatal death,NICU in groupⅠ was significantly higher than that of group Ⅱ (11.6%v s4.0%,12.4vs3.7%,6.6%vs1.1%,5.8%vs3.5%,8.3%vs1.8%,5.0%vs1.3%and33.9%vs14.3%,P＜0.01orP＜0.05),no differ-ence was shown between the two groups in the rate of newborn or fetal deformity,largefor gestational age,neonatal respiratory distress syndrome(P＞0.05)Conclusion:Gestationalabnormal glucose metabolism when complicated with family history of hypertension, pre-pregnancyBMI≥25kg/m~2will increase preeclampsia risk.The incidence of the maternal and fetaladverse outcomes would be further increased when complicated with preeclampsia.