Glutamine Recover After Gastric Intestinal Inflammation And Affect The Immune Status Of Research

Objective: to study the application of glutamine on postoperative intestinal inflammation, restore therole of gastric cancer and the impact on the postoperative immune status and prognosis of value.Methods: the study of2011to2012of henan province tumor hospital general surgery patients of60cases of patients with gastric cancer radical, divided into conventional PN group30cases in accordancewith the principle of randomized, controlled with glutamine (Gln), as well as the PN group and controlgroup:30cases of PN group: to heat nitrogen and so on, in postoperative continuous application7days; Itsformula is: heat125kj,1kg-, d-1, sugar, fat percentage6:4, nitrogen was0.15~0.2g, kg-1, d-1, hotnitrogen ratio is150kal:1g, the nitrogen source from8.5%of all life to provide vitamin LeWei him andhis horse (water), trace elements (anda), electrolytes, regular insulin in clinical routine to give regularchecks and adjustments; All-in-one nutrient solution through central vein input, daily infusion time>12h.Gln group: on the basis of the conventional group, add Gln in PN, according to the supply of20g, d-1.Preoperative application of SPSS software to compare two groups in postoperative hemoglobin, albumin,transferrin, stomach and TNF alpha,1, IL-6and IL-sIgA, CD8+serum content of differencesResults:1. Nutrition indicators:Determination of hemoglobin value comparison: comparison between groups: Gln group was(122.31±12.21) for7days after the determination of value is significantly higher than normal group116.53±19.42(p <0.05). Is: in the group and normal group of112.43±13.435days postoperatively wasslightly higher than92.11±12.67preoperatively (p <0.05);122.31±12.21postoperative day7Gln groupwas obviously higher than that of116.53±19.42preoperatively p <0.05).Albumin assay value comparison: comparison between groups: postoperative day3of the measuredvalue of Gln group27.11±2.31,32.13±3.15is significantly higher than normal group (p <0.05). Groupcomparison:27.11±2.31postoperative day3regular group was obviously lower preoperatively to33.21±33.21(p <0.05); Day5postoperatively31.21±3.32regular group was obviously lower33.65±3.22preoperatively(p <0.05);32.44±3.13postoperative day7normal group was obviously less than34.22±2.85 preoperatively (p <0.05)Transferrin assay value comparison: comparison between groups: Gln group7days after thedetermination of value of2.21±0.75is significantly higher than normal group of1.87±0.44(p <0.05).Group comparison:3,5days postoperatively routine group was obviously lower preoperative (p <0.05);The postoperative day72.14±0.54Gln group was obviously lower preoperative2.28±0.63(p <0.05)Gastric dynamic element determination value comparison: comparison between groups: Gln groupmeasured value of postoperative day7122.25±21.33,137.32±23.01is significantly higher than normalgroup (p <0.05). Group comparison:115.33±19.555days postoperatively routine group was obviouslylower142.31±17.75preoperatively (p <0.05).2inflammatory indicators:Determination of TNF alpha value comparison: comparison between groups: Gln group of measuredvalue of0.65±0.045days postoperatively significantly lower than the conventional group0.69±0.02(p<0.05). Group comparison:0.69±0.025days postoperatively routine group was obviously lower0.75±0.03preoperatively (p <0.05).IL-1measurement value comparison: comparison between groups: Gln group7days after thedetermination of value of0.56±0.010.76±0.03significantly lower than the conventional group (p <0.05).Is: in the group and normal group5days after0.63±0.04below0.66±0.05preoperatively (p <0.05);0.51±0.055days postoperatively Gln group was obviously lower0.76±0.04preoperatively (p <0.05).IL-6determination value comparison: comparison between groups: postoperative day7of Gln groupdetermination value of0.55±0.02less than±0.030.62higher than conventional group (p <0.05). Is: in thegroup and normal group, postoperative day70.62±0.03below0.65±0.04preoperatively (p <0.05); Thepostoperative day70.55±0.02Gln group was obviously lower0.66±0.02preoperatively (p <0.05).3the immune status indicators:SIgA determination value comparison: comparison between groups: postoperative day7of Gln groupdetermination value of0.86±0.05is significantly higher than normal group of0.65±0.04(p <0.05). Is: inthe group and normal group3,5, and7days after0.65±0.04、0.58±0.03,0.45±0.04, significantly higherthan the0.87±0.05(p <0.05); Gln group3,5, and7days after0.86±0.05,0.67±0.02,0.56±0.02,significantly lower than the1.02±0.04(p <0.05). CD4+determination value comparison: comparison between groups: postoperative day7of Glngroup determination value of32.32±2.34is significantly higher than normal group of26.44±1.87(p <0.05). Is: in the group and normal group3,5, and7days after23.33±2.64,2.64±1.87,32.32±2.34,significantly lower than the34.33±2.75(p <0.05); Gln group3,5,7days significantly lower than thepreoperative (p <0.05).CD8+determination value comparison: comparison between groups: Gln group of measured value of35.31±2.765days postoperatively significantly higher than the normal group was27.22±2.83(p <0.05).Is: in the group and normal group3,5, and7days after22.11±2.54,32.32±2.35plus or minus38±3.16and significantly lower than the preoperative (p <0.05); Gln group3,5, and7days after30.32±3.75, and3.75±2.76,34.32±2.53, significantly lower than the preoperative36.14±2.87(p <0.05).Conclusion:Glutamine support in postoperative gastric cancer treatment can improve the nutritional status ofpatients, increase protein synthesis; Can reduce the expression of inflammatory factor; Can improve thepatient’s immune function, to provide patients with stress ability.