The Clinical Significance Of Measuring Serum Thymidine Kinase1in The Patients With Esophageal Carcinoma

AIM:To investigate the diagnostic value of serum thymidine kinase1(TK1) in carcinoma of the esophagus.METHODS:The serum level of TK1was determined by enhanced chemi-luminescence assay(ECLA) in158patients with carcinoma of the esophagus(group A),40cases with benign disease(group B) and50normal control s(group C). Next, we randomly selected28patients from the158patients; we investigated the content of serum TK1of7days and1month after operation.RESULTS:The level of TK1was3.34±0.83(0.23～32.3) pmol/L in group A,which was significantly higher than1.30±0.48(0.21～3.24) pmol/L (P<0.01) in group B or than1.14±0.33(0.1～2.24) pmol/L (P<0.01) in group C(P<0.01). There was no significant difference in serum TK1between group B and group C (P>0.05). The level of the28patients STK1was3.04±0.89(0.23～11.69) pmol/L, the7days after operation level was2.48±0.63(0.34～7.87) pmol/L (P>0.05)and the1month after operation level was1.25±0.28(1.11～2.64) pmol/L (P<0.05)after operation.CONCLUSION:The detection of serum cytoplasmic thymidine kinase is not only used for the diagnosis of esophageal carcinoma, can also be used to monitor the surgical treatment of esophageal carcinoma.