Effects Of Pubertal Exposure To Bisphenol A On Cognitive And Behavioral Development In Mice

Objective To explore the effects of pubertal exposure to bisphenol A (BPA) oncognition and anxiety-related behavior in mice, and whether the effects is persistent.Methods Randomly divided into three groups, mice were orally administered witheither water or BPA (1or100mg/L) from PND28-PND56. Morris Water Maze wasperformed to assess learning and memory. Open Field Test, Black-White Alley andElevated Plus Maze were performed to assess exploration and anxiety-related behaviors.Results The results were showed by M士SE, and analyzed by SPSS10.0.1. There was no disease, infection and death during adolescence and adulthood, theweight was no statistically significant difference.2. In Morris water maze test, pubertal BPA exposure prolonged escape latency and swimdistance in female mice during early adulthood (P <0.05), but not in male mice.3. In the Open-Field test, there was significant decrease on latency in female miceduring early adulthood. Compared with controls, rears were altered in females duringearly adulthood and in males during adulthood (P <0.05).4. In black-white alley test, significant difference was observed on time in black alley infemales (P <0.05).5. In aggressive test, latency were prolonged in males compared with controls during early adulthood (P <0.05).Contact time were increased compared with controls in malesduring early adulthood and during adulthood (P <0.05).Conclusion Pubertal BPA exposure impaired spatial learning and memory in agender-specific manner. In addition, pubertal BPA exposure persistently disruptsexploration, anxiety and aggressive behavior.