The Outcome Of Low Ovarian Response Occurred In IVF/ICSI-ET Of Modified Long Down-regulation Protocol

Objective：To explore the outcome of poor ovarian responders undergoing modified longdown-regulation protocol and to estimate the prospect of clinical application of the protocol in clinical.MethodsThis retrospective study performed from January2010to March2012.752cycles in modified longdown-regulation protocol and538cycles undergoing long down-regulation protocol in IVF/ICSI were included.General conditions and the outcome of poor ovarian responders in two protocols were compared.Compare generalconditions、NO. of retrieved oocytes、mature oocytes rate、fertilization rate、cleavage rate、high-qualityembryo rate、clinical pregnancy rate、implantation rate、abortion rate、live birth rate of the embryotransferred cycles in two protocols，respectively616、473cycles。Poor ovarian responders in modified longdown-regulation protocol and that in long down-regulation were compared，included general conditions、NO. ofretrieved oocytes、mature oocytes rate、fertilization rate、cleavage rate、high-quality embryo rate、clinical pregnancy rate、implantation rate、abortion rate、live birth rate。Result: There was no significantdifference in average age、average number of retrieved oocytes、average transferred embryos between the twoprotocols. The clinical pregnancy rate, implantation rate and live birth rate per embryo transfer in modified longdown-regulation protocol were significantly higher and the abortion rate was significantly poorer than that in longdown-regulation protocol (P＜0.05). There was no significant difference in the rate of poor ovarian responsebetween the two protocols. Compare with PORS in long down-regulation protocol，clinical pregnancy rate、implantation rate and live birth rate of poor ovarian responders in modified long down-regulation protocol werehigher，abortion rate was lower，had statistically significan（tP＜0.05）。When focus on the patients encounteringpoor ovarian response, the dose of gonadotropin was higher and duration of stimulation was longer in modifiedlong down-regulation protocol and there was no significant difference in the number of oocytes retrieved, the cancellation rate and the abortion rate between two groups. The pregnancy rate, implantation rate and the livebirth rate per embryo transfer in poor ovarian response patients were significantly higher in modified longdown-regulation protocol in comparison with that of long down-regulation protocol.