Expression And Their Significance Of SOX-17and COX-2in Cervical Cancer

ObjectiveTo investigate the expression of SOX-17,COX-2in normal cervix, cervicalintraepithelial neoplasia (CIN) and cervical cancer as well as their correlations. Thefurther study aims to examine the role of SOX-17and COX-2in the development ofcervical cancer.MethodThe expression of SOX-17,COX-2was studied by immunohistochemicalSP(Streptavidin-biotin perxidase link method) in60cases of cervical cancer,73cases ofCIN and24cases of normal cervical tissues.Results1.The positive rates of SOX-17in normal cervix, CIN, cervical cancer were91.7%、53.4%、28.3%,what showed that the SOX-17expression level decreased gradually withthe progression of cervical lesions. The positive rate of the normal cervical tissues washigher than in CIN and cervical carcinoma (P＜0.05). The level of SOX-17was higherin cervical intraepithelial neoplasias compared with cancer samples (P＜0.05). therewas significant difference statistically significant in the different grade of the CIN(P＜0.05).2.The positive rates of COX-2in normal cervix, CIN, cervical cancer were12.50%、52.05%�'�90.00%,what showed that the COX-2expression level increased gradually with the progression of cervical lesions. The positive rate in the CIN and cervicalcarcinoma was higher than normal cervical tissues. The level of COX-2was higher incancer samples compared respectively with cervical intraepithelial neoplasias, therewas significant difference statistically significant in the different grade of the CIN(P＜0.05).3. SOX-17showed a negative correlation with the change of COX-2. Spearson r=-0.369, the correlation analysis showed that SOX-17and COX-2have a closed relationand together participate in the development cervical cancer.Conclusion1.SOX-17had high expression in normal cervical tissue but low expression in cervicalcancer,suggesting that its low expression might relevantand the pathogenesis ofcervical cancer.2. COX-2was highly expressed in cervical cancer and closely related to theclinicopathological grades of cervical cancer, which indicated COX2might play a rolein the development of cervical cancer.3.SOX-17, COX-2might be involved in the occurrence and the development ofcervical cancer,which might provide cervical targeted therapy of cancer research.