| ObjectiveTo explore the cognitive states and the relevant factors in patients with chronicobstructive pulmonary disease （COPD）.MethodsTwenty-five mild-to-moderate, thirty severe COPD patients and twenty-five controlsubjects were recruited. Cognitive states were investigated by mini mental stateexamination （MMSE）. Pulmonary function, arterial blood gas, serum clusterinconcentration and MRI volumes of hippocampus were evaluated in each subject.ResultsMMSE scores in mile-to-moderate COPD, severe COPD and control group were:24.80±1.91,22.83±2.78, and27.52±2.99；left hippocampal volumes were:2.43±0.28cm3,2.31±0.27cm3, and3.62±0.40cm3；right hippocampal volumes were:2.56±0.32cm3,2.46±0.34cm3, and3.75±0.46cm3；total hippocampal volumes were:4.98±0.48cm3,4.77±0.58cm3, and7.37±0.82cm3；the concentrations of serum clusterin were：148.40±12.63μg/ml,167.70±19.24μg/ml, and119.30±11.70μg/ml。Lower levels of theMMSE scores and higher concentrations of serum clusterin were found inmild-to-moderate COPD group（P<0.01）, while the lowest level of the MMSE scoresand highest level of serum clusterin were found in severe COPD group（P<0.01）compared to control group. The MRI volumes of hippocampus declined in both of the two COPD groups. The MMSE scores were significantly positively correlated with thelevels of arterial oxygen tension （PaO2）（r=0.45，P<0.05; r=0.39, P<0.05） and serumclusterin concentrations were negatively associated with PaO2（r=-0.51, P<0.01;r=-0.36, P<0.05） and MMSE scores（r=-0.52, P<0.01；r=-0.62, P<0.01）in bothmild-to-moderate and severe COPD groups In addition, the forced expiratory volumein one second （FEV1） was positively related with MMSE scores （r=0.42, P<0.05） andnegatively correlated with the serum clusterin concentrations （r=-0.41, P<0.05） insevere COPD group.ConclusionLower levels of cognitive function and atrophic volumes of hippocampus were foundin COPD patients, which are correlated with the classification of severity, PaO2, FEV1and concentrations of serum clusterin. The cognitive impairment of COPD may be oneof the basic diseases of preclinical Alzheimer’s disease （AD）. |
