Association Between Endothelin And Coronary Artery Calcification

Objective To study the association between endothelin and coronary artery calcification(CAC).Methods A total of424consecutively admitted patients from Feb2011to Feb2012in Fu Wai Hospital were analyzed. All patients had received coronary angiography and coronary computed tomography angiography (CCTA) then divided into two groups based on the results of coronary calcium score. The clinical information included classical coronary artery disease (CAD) and calcification risk factors, and Big ET-1was analyzed to identify their relationship to CAC.Results Some traditional cardiovascular risk factors were statistically significant associated with patients who existing calcification. These included, diabetes mellitus, hypertension and hyperlipidemia (P=0.001).Patients with CAC had significantly elevated HbAlc, hs-CRP, Big ET-1levels compared with those without CAC (P=0.002, P=0.001). In the multivariate analysis, age, Big ET-1,hypertension,hyperlipidemia and HbAlc (P=0.001, P=0.002, P=0.004, P=0.048, P=0.047) appeared as independent factors predictive of presence of CAC. In a receiver operating characteristic (ROC) curve analysis, a Big ET-1value of0.59was identified as an effective cut-point in the segregation of the presence or absence of CAC [area under curve (AUC)=0.65,95%CI:0.58-0.72], and an Big ET-1value of more than0.59yielded a sensitivity of50.1%, a specificity of76.1%.Conclusion We demonstrated a significant correlation between ET and CAC. ET was an independent predictor of CAC.