Risk Factors Of Breast Cancer And The Relationship Between Risk-factors And The TNF-α

Background and purpose: This is the investigation of dalian area of femalebreast cancer related risk factors，provides the basis for individual assessment the risk ofbreast cancer women. Explore breast cancer patients at high risk of developing breastcancer related factors to promote the related mechanism, provides the theory basis forindividual therapy.Methods: A questionnaire and reference international anxiety at home and abroadwith depression self rating scale, including the general situation, diet article andpsychological article, epidemiology, the educational research group and statistics to beapproved by the educational research group.The object of life in dalian area10years of breast cancer and healthy women, faceto face the investigation, the application of Logistic regression analysis with the breastcancer related risk factors.According to the risk factors of high value OR depression factors, will be dividedinto high-risk group of patients with breast cancer, and the tumor high-risk group,through the immunoistochemical method detection in breast cancer, the cancer tissuecancer organization necrosis factor TNF-α and the surrounding normal tissue of theexpression and clinical features of relevancy.Results:1. Dalian area of breast cancer among women related risk factors, BMI (bodymass index, BMI), anxiety, depression and onion garlic less intake for the single factoranalysis results; Many factors of regression analysis results and Logistic condition: BMI(body mass index, BMI) quartile24, anxiety, depression for dalian breast cancer riskfactors.2. Depression and TNF alpha express correlation studies of the results: (1)In breast cancer depression cancer tissue group called TNF-α positive ratewas79.3%, the depression cancer tissue group called rate was55.6%, expression areincreased, but between the two groups no significant difference (P>0.05);(2)Breast cancer depression cancer tissue group called TNF-α positive rate was79.3%, the cancer organization positive rate was24.1%, P <0.05statistically significant;Breast cancer tissue adjacent to depression group the positive rate was24.1%, thenormal tissue around the positive TNF-α was16.0%,(P <0.05)(3)No-depressed group of carcinoma of breast cancer organization positive ratewas55.6%, the cancer organization positive rate was12.5%,(P <0.05) statisticallysignificant; The depression of carcinoma positive rate was12.5%, surroundingnormal breast cancer tissue adjacent was2.9%,(P <0.05) statistically significant;(4)Breast cancer tissue adjacent to cancer depression group called positive ratewas24.1%, the depression by the organization of cancer called positive rate was12.5%, P <0.05, statistically significant; Breast cancer the positive ratewas depression in normal tissue around the group called16.0%, the depression of thesurrounding normal tissues of positive rate was2.9%,(P <0.05) statisticallysignificant;(5)Further stratified analysis, cancer organization called expression and breastcancer is closely related to the lymph node metastasis, P <0.05, statistically significant.Conclusion:1. The body mass index (BMI) high, anxiety, depression for dalian female breastcancer risk factors for breast cancer prevention and control of the extensive providesdirection.2. The depression and cancer risk factors and the surrounding tissue adjacent innormal tissue tumor necrosis factor was positively related to express, indicating that thedepression may raise the body through tumor necrosis factor expression changed theimmune state influence breast cancer, invasion and metastasis.