The Responsiveness Of Stroke Volume Variation And Central Venous Pressure During Volume And Pressure Loading

Objective:The aim of the study was to compare the sensibility of stroke volume variation (SVV) by Vigileo/Flotrac system with central venous pressure (CVP) in patients undergoing volume and pressure loading.Methods:30patients scheduled for neurosurgery were randomly divided into VL group (n=15) and PL group (n=15). All the patients met following criteria:ASA Ⅰ-Ⅱ,35-65years old. All the patients involved received general anesthesia and mechanically ventilated. Patients in VL group received6%hydroxyethyl starch130/0.4(HES) infusion at the speed of35-40ml/min when patient’s BP was75%below base value, and discontinued as BP come back to80%of the baseline. Adversely, lOug/min of Phenylephrine was infused and discontinued in the same condition in PL group. SVV, CVP and other hemodynamic parameters were obtained at baseline,1min,2min,3min,4min,5min,6min,7min,8min,9min,10min,15min, and20min after volume or pressure loading.Results:There was significant decrease in the value of SVV (from14.47±7.22to6.67±1.72;14.47±7.22to6.53±2.39, P<0.05) at15min and 20min in VL group after6%HES infusion, while there was no significant difference in the value of CVP at all time. There were no significant differences in the value of SVV and CVP in PL group during study.Conclusions:SVV significantly decreased while CVP had no significant difference in the value as circulating volume increased in hypovolemia patients. Increasing pressure loading had no effect on the value of SVV and CVP.