Mine Disaster Patients’ Lung Function Evaluation And The Influencing Factors

ObjectiveRetrospective analysis of "3.28" WangJiaLing miners’lung ventilation function and small airway function test results, to explore the influence factors of the change and relation with serum electrolyte change, further clarify the importance of the full complement of electrolyte to starvation, and improve the clinical for hungry again after treatment principle in the process of eating.MethodsSelected46cases from "3.28" Wangjialing coal mine accident rescue workers for the experimental group,51cases of healthy subjects as the control group, and the age, gender, height and weight of two groups were matched. Collect venous blood samples of all patients who are admitted to hospital1-3days for electrolytes, bilirubin, uric acid, protein concentration before, C-reactive protein, fibrinogen and other indicators of the original determination. All patients in the hospital for6-8days after the first line of pulmonary function tests, using the measured values expressed as percentage of predicted value accounted for the results. SPSS16.0statistical software used to establish a database of indicators will be entered into the database and the statistical analysis:①The experimental and control groups pulmonary function test results were compared.②Small airway function changes influencing factors:the dependent variable for the experimental group of small airway function, the argument is a history of smoking, electrolytes, upper respiratory tract infection, uric acid, serum bilirubin, prealbumin, C-reactive protein, fibrinogen.③Correlation analysis: analysis of serum electrolytes and small airway function correlation.Results1Two pulmonary lung function test results In the lung function test results, the indicators of lung function of the experimental group compared with the control group were lower. Including FVC, FEV1, FEV1/FVC values than the control group (t=2.903,2.401,3.325, P<0.05), PEF, FEF25values were significantly lower than the control group (t=8.692,9.912, P<0.001), the difference was statistically significant. Small airway function test results, the experimental group compared with the control group, small airway function FEF50, FEF75, MMEF was significantly lower than the control group (t=7.529, t=7.181, t=7.707, P<0.001), the difference statistically significant. FEF50and FEF75abnormal high rate of small airway dysfunction29(46) cases, the difference between the two groups was statistically significant abnormal rate.2Influencing factors This study investigated8factors, and5factors collected into the regression equation:smoking history, electrolyte disorders, upper respiratory tract infection as risk factors. Exclude of other confounding factors, the risk increased19.844,14.861,28.925times. Hyperuricemia and hyperbilirubinemia were protective factors. Getting rid of other confounding factors, the risk of the control group were6.2%and2.3%.3Serum electrolytes correlation between lung function Serum potassium, sodium, calcium concentration have no correlation with small airway function changes; the changes of serum phosphorus and magnesium concentration respectively relate with FEF50and FEF75linear regression. From the standardized regression coefficients, we can see that magnesium has the most significant influence on FEF50and FEF75(r=0.887, r=0.879, both p<0.001).Conclusion1Starvation, dehydration can affect pulmonary function, airway function was reduced to the more obvious, FEF50and FEF75are to determine a sensitive indicator of small airway function.2Electrolyte disorders and upper respiratory tract infections are risk factors cause small airway disease. 3Reasonable added electrolytes, particularly serum phosphorus, magnesium caused starvation pulmonary disorders has important clinical significance.4Under starvation, dehydration state, serum bilirubin and uric acid may be the body of a protective adaptive response.