The Clinical Study Of The Combination Therapy With Oral Isotretinoin And Topic Treatments In Moderate And Severe Acne

Objective: To explore the clinical efficacy and safety of the combination therapyin moderate to severe acne.Methods: According to the diagnostic criteria and severity of acne, we selected110cases of moderate to severe acne from outpatients, there are105patients completedthe trial, another5patients terninated of the trail because of adverse reactions.agedbetween18～36. They were randomly divided into three groups:33cases for group A,38cases for group B, and39cases for group C. Learnt the basic conditions of thesepatients and the relevant factors of the onset detailly, and explained the considerationsto these patients carefully before treatment. These patients cleaned facial skin beforeeach time of treatment. A same observer determined the extent and type of the lesions,recorded the conditions of the lesions, and evaluated the efficacy and safety. The NikonD60digital camera (Japan) acquested the images of skin lesions. Group A: oralIsotretinoin Soft Capsules＋0.5%Benzoyl peroxide Water base gel＋Anti-Acne（WINONA）, for continuous8weeks. Group B: oral oral Isotretinoin Soft Capsules＋0.5%Benzoyl peroxide Water base gel, for continuous8weeks.Group C: oralIsotretinoin Soft Capsules＋Anti-Acne （WINONA），for continuous8weeks.oral oralIsotretinoin Soft Capsules＋0.5%Benzoyl peroxide Water base gel, for continuous8weeks. The observer observered the changes of the lesions and adverse reactions4weeks and8weeks after the treatment.Results: The gender, age, disease progression and severity of acne of three groupsof patients had no statistical differences (P＞0.05). After treatment for4weeks, the totaleffective rates of the group A, B and C were68.75%、60.00%、57.90%,respectively.And after treatment for8weeks, the total effective rates of the group A, B and C were90.63%、82.85%、81.58%,respectively. The data showed there were no statisticaldifference of the curative effect among the three groups. However total effective rate of treatment course8weeks was significantly higher than treatment course4weeks(P<0.05). There were4cases,50cases,42cases and9cases took effect after treatmentfor one, two, three and four weeks respectively. Adverse reactions included dry mouth(71cases), cheilitis (7cases), skin dry and desquamation (14cases), itching (10cases)and epigastric discomfort (5cases), and which recovered in the short term withoutgiving any special treatment. Furthermore the percentane of skin dry and desquamationand itching were were significantly higher in the group B than in the group A and C(P<0.05).Conclusions: Using triple therapy, group A outperformed the others. Tripletherapy in moderate to severe acne can act on multiple links of acne pathogenesis, theirsynergies enhance the effect. With the fast onset time, short courses, and the highremission rate, you can obtain a satisfactory outcome and no the apparent occurrence ofadverse reaction. The medical skin care product has a high security and a adjunctiveeffect on the therapy of acne.