Correlation Between Aggressive Behavior And Thyroid Hormone And Testosterone In Schizophrenic Patients

Objective: To explore the correlation between aggressive behavior and thyroidhormone and testosterone in schizophrenic patients.Methods: According to the past violence history and raings on Modified OvertAggression scale(MOAS),80the first inpatients with schizophrenia were divided intotwo groups of aggressive (research group) and non-aggressive (control group).Bothserum thyroid hormones（TSH、FT3、FT4、TT3、TT4）and Serum testosterone werecompared between two groups. Correlation analysis was buit up within the group ofthyroid hormones and serum testosterone.And correlation of the hyroid hormones andtestosterone levels with Positive and Negative Syndrome Scale(PANSS）and MOASwas built up.Results: TSH level of within research group was negatively correlated withTT4. TSH level of research group[(4.749±1.100) mIu/L] were higher than those ofcontrol group [(4.305±0.796) mIu/L](P=0.042).TSH level of research group waspositively correlated with MOAS aggression towords others subscores (r=0.341,P=0.031); FT3level of research group[(6.48±2.13) pmol/L] were significantly higherthan those of cotrol group[(4.92±0.87) pmol/L](P=0.000), FT3level of researchgroup was positively correlated with PANSS subscores (positive symptomssubscores,r=0.338P=0.033; anxiety-depression symptoms subscores, r=0.349P=0.027); FT3level of the research group was positively correlated with MOASauto-aggression symptoms subscores (r=0.322,P=0.043);TT3level of research group[(2.00±0.35) nmol/L] were significantly higher than those of control group[(1.75±0.39)nmol/L](P=0.004), which was negatively correlated with PANSS cognitivesymptoms subscores(P=0.024);TT4level[(78.96±10.16)nmol/L] was significantlydecreased in the research group as compared with control group [(90.82±10.37)nmol/L](P=0.000). TT4level of the research group was negatively correlated with MOAS(verbal aggression r=0.368, P=0.020and aggression against property r=0.328P=0.039).Serum male testosterone level of the research group was significantlyincreased as compared with control group(P=0.008). Serum male testosterone level ofthe research group was positively correlated with MOAS aggression towords otherssubscores (r=0.315,P=0.048); FT3level of control group was positively correlatedwith PANSS positive symptoms subscores r=0.415, P=0.008);FT3level of the controlgroup was positively correlated with PANSS anxiety-depression symptoms subscores(r=0.336,P=0.034).Conclusion: Aggressive behaviour may be positively correlated with TSHand FT3level in schizophrenic patients,which may be positively correlated withSerum testosterone level in male schizophrenic patients.