Clinical Analysis Of Susceptibility And Risk Factors Of Colorectal Adenomas

Objective: To investigate the risk factors of colorectal adenomas and its atypicalhyperplasia, so as to provide better monitoring to the development and canceration ofadenomas; further raise the level of early prevention, diagnosis and treatment ofcolorectal cancer.Methods: Selected212inpatients of colorectal adenomas from our hospitalduring January2002to September2011as the case group, and150outpatients who hadundergone colonoscopy but not found obvious abnormalities from December2011toMarch2012as the control group. With the colonoscopy-based case-control study,Logistic regression model was used for univariate and multivariate analysis ofcolorectal adenomas. First, the significant factors were selected by univariate analysis,then they were brought into multivariate analysis of Logistic regression model. Inaddition, rank-sum test was used to analyze the relationship between adenomas size,surface characteristics and pathological type with degree of adenomatous atypicalhyperplasia of the case group respectively.Results: The susceptibility and risk factors of colorectal adenomas included age,chronic diarrhea, mucous-bloody-stool, frequent constipation, abdominal pain,abdominal distension, abdominal discomfort, family history of cancer, appendectomy,regular smoking (≥10cigarettes per day, and≥1year), tumor marker CEA. Nomeaningful protection factor was discovered. In addition, the case group was separatelyanalyzed and found out that adenomas size, surface characteristics and pathological typewere related to atypical hyperplasia of colorectal adenomas.Conclusions: The risk factors of colorectal adenomas included family history ofcancer, appendectomy, regular smoking (≥10cigarettes per day, and≥1year), elevatedCEA, stool character changes, such as: chronic diarrhea, mucous-bloody-stool, frequentconstipation, clinical symptoms as abdominal pain, abdominal distension, abdominal discomfort; in addition, age was also susceptibility factor for colorectal adenomas.Inaddition, adenomas size, surface characteristics and pathological type were closelyrelated to degree of atypical hyperplasia grading, and endoscopic cilnicians could donecessary biopsy by the the observation of adenomas size, surface characteristics withcolonoscopy.