The Relationship Between Resilience And Treatment Side Effect, Quality Of Life In Cancer Patients Undergoing Radiotherapy/Chemotherapy

[Object]The primary goal of the study was to describe the psychological status of cancerpatients treated with radiotherapy/chemotherapy, consider the relevant factors ofresilience; determine if resilience influences gastrointestinal toxicity effect andQuality of Life in a sample of cancer patients treated with radiotherapy/chemotherapy.Research a cutoff value of the resilience-14, to identify the levels of patients’resilience, in order to provide the basis for carry on clinical psychological care andpsychological intervention, and for reduce treatment side effects, improving thequality of life.[Method]Inpatients who were diagnosed as cancer and underwentradiotherapy/chemotherapy were recruited in this study in the Fujian ProvincialCancer Hospital、Union Hospital、Fujian provincial hospital、General Hospital、Thefirst affiliate hospital of Fujian medical university from October,2010to October,2012. The demographic data (age, gender, vocation, educational, religious belief,support) and clinical information (site of the tumor, clinical stage) were collected byquestionnaires. Then reassessed at the point of therapy3weeks later, measurecomprised the Resilience Scale (RS), Hospital Anxiety and Depression Scale (HADS),the EORTC QLQ-C30as a measure of health related Quality of Life, and evaluationgastrointestinal toxicity effect. Multiple linear regression analyses were used toanalyze resilience influencing factors and the relationship between resilience withanxiety and depression. Chi-squares test was used to compare the side effects betweenthe different levels of resilience; spearman correlation to determine the relationship ofresilience and QoL; logistic regression analysis the gastrointestinal side effects relate to resilience. A structural equation modeling was built to assess the role of resilienceon the QoL. In order to find the optimal prediction cut-off point, curve estimationswere used.[Results]1. There were816patients collected. Multiple linear regression analysesrevealed that gender、educational, along with support, associated with resilience, evenafter controlling for the effects of illness severity.2. Multiple linear regression analyses indicate that resilience associated withanxiety and depression, after controlling for the effects of age、 gender andeducational.3. Logistic regression analysis shows that resilience was the protective factor ofgastrointestinal side effects, while anxiety was risk factor.4. Structural equation modeling suggests that resilience has indirect effects onQoL, through anxiety and depression.5. When resilience score was57, the cut-off point was optimal, sensitivity andspecificity were0.746and0.623respectively.[Conclusion]1. Gender、educational and support associated with resilience.2. Resilience has a negative relationship with anxiety and depression, and itcould adjust psychological state.3. Resilience and anxiety independent contribution to gastrointestinal side effects,resilience has positive correlation with QoL by anxiety and depress.4. Those whose resilience score was less than57represent that low level ofresilience, should be given psychological intervention, while the others should not.