Correlationship Of Plasma Apelin-12with Blood Pressure And Early Renal Damage In Hypertensives

ObjectivesWe conducted this survey to explore the relationship between plasma Apelin-12and angiotensin II (Ang II). Furthermore, we want to know the correlationship ofplasma Apelin-12and Ang II with blood pressure and early renal damage inhypertensives, therefore to provide clinical data for the intervention and therapy ofhypertension and its early renal damage.MethodsThree hundred and fifty-four apparently healthy people (control group) and317patients with essential hypertension (hypertensive group) were selected from across-sectional investigation in coastal area of Fujian Province to test the levels ofApelin-12, Ang II, serum creatinine, urine creatinine and urinary albumin. The levelsof Apelin-12, Ang II, urinary albumin creatinine ratio (UACR), estimated glomerularfiltration rate (eGFR) were compared between hypertensive group and control group.Linear trend test, pearson correlation analysis and multiple linear regression analysiswere conducted to find out the relationships separately between blood pressure andApelin-12, blood pressure and Ang II. Pearson correlation analysis and multiplelinear regression analysis were conducted to explore the correlationship of Apelin-12and Ang II. With the combination of the hypertensive group data, UACR levels wereclassified into two groups of hypertension with early renal damage and hypertensionwithout early renal damage by30mg/g to compare Apelin-12and Ang II levels indifferent groups. Moreover, eGFR levels were classified into tierce groupings tocompare Apelin-12and Ang II levels in different groups. Pearson correlation analysisand multiple linear regression analysis were conducted to explore the correlationshipsseparately between Apelin-12and UACR, Ang II and UACR, Apelin-12and eGFR,Ang II and eGFR. Results1. The levels of Apelin-12and eGFR in hypertensives were lower than those in thehealthy controls (P<0.01), but the levels of Ang II and UACR in hypertensiveswere higher than those in the healthy controls (P<0.01).2. There were linear trends separately between blood pressure and Ln(Apelin-12),blood pressure and Ln(Ang II)(P<0.05). As blood pressure elevated,Ln(Apelin-12) went down and Ln(Ang II) went up. Mean arterial pressure (MAP)was negatively associated with Ln(Apelin-12)(P<0.01), but positively associatedwith Ln(Ang II)(P<0.01). This association existed after adjustments for age, sex,blood lipid and body mass index (BMI), etc.3. Ln(Apelin-12) was negatively correlated with Ln(Ang II)(P<0.01). Thisassociation existed after adjustments for age, sex, systolic blood pressure, diastolicblood pressure, blood lipid and BMI, etc.4. In the group of hypertension with early renal damage, the level of Apelin-12waslower (P<0.05) and the level of Ang II was higher (P<0.05). Ln(UACR) wasnegatively associated with Ln(Apelin-12)(P<0.01), but positively associated withLn(Ang II)(P<0.01). This association existed in the controls of sex, age, MAP,blood lipid and BMI, etc.5. In the hypertension with minimum set of eGFR, the level of Apelin-12was thelowest and the level of Ang II was the highest (P<0.05). Ln(eGFR) was positivelyassociated with Ln(Apelin-12)(P<0.01), but negatively associated with Ln(Ang II)(P<0.01). This association existed in the controls of sex, age, MAP, blood lipidand BMI, etc.Conclusions1. As blood pressure elevated, the level of Apelin-12went down and the level ofAng II went up.2. Apelin-12was negatively correlated with Ang II.3. In hypertensives with early renal damage, the level of Apelin-12was low and thelevel of Ang II was high.