Amplitude Of Low-frequency Fluctuation In Patients With VCIND’s Disease Based On Resting-state Functional MRI

Objective:To investigate the baseline brain activity level in patients withvascular cognitive impairment,no dementia,（VCIND） by amplitude oflow-frequency fluctuation（ALFF）based on resting-state functional MRI（fMRI）.Methods：Twenty two patients with VCIND（VCIND group）and twentythree volunteers（control group）were examined by resting-state fMRI on GEMR7503.0T. ALFF values of the two groups were calculated and compared.Results： In VCIND group， ALFF values in the left Inferior FrontalGyrus/Superior Temporal Gyrus（IFG/STG,Z=-4.0682),right Inferior FrontalGyrus/Superior Temporal Gyrus （IFG/STG,Z=-3.9720),left InsulaLobe(Z=-3.5773)were higher than those in control group，with statisticallysignificant differences（P<0.05）.The VCIND patients show lower ALFF valuesin Lingual Gyrus/Cerebellum Posterior Lobe(Z=3.8921),Anterior Cingulatecortex（ACC,Z=3.8081),right Cuneus Lobe/Lingual Gyrus(Z=4.8272),bilateralPosterior Cingulate Cortex/Pre-Cuneus (PCC/PCu,Z=3.9741)withstatistically significant differences（P<0.05）.The PCC ALFF analysesshowed that the ALFF values of PCC for both groups had a pattern of ALFFVCIND<ALFFNC(t=2.063，P=0.045). We also found the positive correlationsBetween the ALFF values of PCC and MoCA scores.Conclusion：The VCIND patients’ ALFF had significant increase in thecognitive brain areas such as speech centres and decrease in DMN.