The Study Of Interventional Effects Of Aerobic Training Based On Functional Magnetic Resonance Imaging On Patients With Alzheimer's Disease

Part one:Study on the intervention effect of aerobic training on patients with mild cognitive impairmentPurpose:To evaluate the effects of a specially designed moderate intensity aerobic dance(SDMIAD)on older adults with mild cognitive impairment(MCI)using resting-state functional MRI(RS-fMRI).Materials and Methods:A total of 38 subjects with MCI were enrolled in the study and were randomly assigned into two groups:exercise group(EG,n=19)and control group(CQ n=19).The EG was treated with a SDMIAD for 3 months.The CG received education and usual care.The cognitive assessments and RS-fMRI examination were performed on two groups at baseline and after 3-month.The cognitive functions were assessed by various neuropsychological tests.The brain spontaneous activity change was assessed using an index,amplitude of low-frequency fluctuation(ALFF)of fMRI signal.Results:For cognitive assessments,EG showed improved results in Mini-Mental State Examination,Montreal Cognitive Assessment,Wechsler Memory Scale and Digit Symbol Coding Subtest(p<0.05)and the difference of changes from baseline to 3 months in EG and CG was also statistically significant(p<0.05)after 3-month SDMIAD;while CG showed no difference of all the cognitive assessments.Compared with baseline,EG showed increased ALFF in extensive areas of bilateral fronto-temporal,entorhinal,anterior cingulate and parohippocampal cortex after 3-month SDMIAD;whereas the CG showed increased ALFF in few areas such as right temporal and posterior cingulate cortex.Conclusion:The SDMIAD is helpful to effectively improve the cognitive function in older adults with MCI.RS-fMRI provides a quantitative and sensitive method for evaluating the effect of aerobic exercise on MCI suffers.Part two:Study on the intervention effect of aerobic training on patients with mild Alzheimer's diseasePurpose:To evaluate the effects of a specially designed moderate intensity aerobic dance(SDMIAD)on mild AD patients using resting-state functional MRI(RS-fMRI).Materials and Methods:A total of 40 mild AD patients were enrolled in the study and were randomly assigned into two groups:exercise group(EG,n=20)and control group(CG,n=20).The EG was treated with a SDMIAD for 3 months.The CG received education and usual care.The cognitive assessments and RS-fMRI examination were performed on two groups at baseline and after 3-month.The cognitive functions were assessed by various neuropsychological tests.The brain spontaneous activity change was assessed using an index,amplitude of low-frequency fluctuation(ALFF)of fMRI signal.Results:For cognitive assessments,EG showed improved results in Mini-Mental State Examination and Trail Making Test A(p<0.05)after 3-month SDMIAD;while CG showed no difference of all the cognitive assessments.Besides,the difference of changes from baseline to 3 months in EG and CG was not statistically significant(p>0.05).Compared with baseline,EG showed increased ALFF in left frontal,left anterior cingulate,right parietal,right precentral and post postcentral cortex after 3-month SDMIAD;whereas the CG showed decreased ALFF in bilateral cerebellum,left temporal,right frontal and right anterior cingulate cortex.Conclusion:The SDMIAD is helpful to moderately improve the cognitive function in mild AD patients.RS-fMRI provides a quantitative and sensitive method for evaluating the effect of aerobic exercise on mild AD suffers.Part three:A preliminary study on the mechanism of aerobic training in patients with Alzheimer's disease:a resting-state functional MRI trialPurpose:To explore the mechanism of aerobic dance on AD patients using resting-state functional MRI(RS-fMRI).Materials and Methods:17 cases of patients with AD were randomly divided into exercise group(EG,n=9)and control group(CG,n=8).The EG was treated with a SDMIAD for 3 months.The CG received education and usual care.Both the fMRI data of baseline and after 3-month were got for the amplitude of low frequency fluctuation(ALFF)analysis and analysis of brain functional network.Results:The training group showed increased ALFF value of bilateral prefrontal and anterior cingulate cortex and brain network betweenness centrality(BC)value compared with baseline after 3 months of training,while the BC value of training group was higher than those in control group after 3 months.The difference was statistically significant(p<0.05).Further analysis of the network hubs showed bilateral distribution after training,which was different from the asymmetric distribution before.Conclusion:Aerobic training can effectively increase the spontaneous activity of key brain areas and the efficiency of whole brain information transmission,promote the reorganization of the brain network and the contralateral cerebral hemisphere compensation,and thus contribute to the recovery of cognitive function in AD patients.