| Background: In recent years, many risk factors of coronary heart disease whichwere so-called “diseases of affluence” such as hypertension、diabetes、dyslipidema、0besity which occurred in the western developed countries in the past have become ahigh trend in the urban and rural of China，with the improvement of the living standardsof people，so coronary heart disease has become a common disease in our country.According to statistics, the mortality of coronary heart disease which has exceeded thesum of all tumors, listed the first in the cause of death. Coronary heart disease hasbecome a hot research for scholars, its specific pathogenesis which is not yet clear,continues to explore. Inflammatory response which was raised as a new view of thepathogenesis of coronary heart disease in1999, is now accepted by most scholars.pentraxin3(PTX3) have shown that certain associated with the incidence of coronaryheart disease as a new inflammatory factor.Objective: To observe plasma PTX3expression levels and change in the patients ofdifferent types coronary heart disease, and to observe the relationship with plasma PTX3expression levels and the different levels of coronary lesions. To observe its ability indiagnosis of acute coronary syndrome, in order to provide a more precise laboratory basisfor early diagnosis, assessment and treatment of coronary heart disease.Methods：The experimental group involved71patients in the Department ofcardiology, who were diagnosed coronary heart disease. Their average age were63.13±4.86years. There were50male patients and21female patients. We put them intothree groups by the different types of coronary heart disease.21subjects assigned into group SAP,24subjects assigned into group UAP,26subjects assigned into group AMI.UAP group and AMI group were combined ACS group which had50patents. In thesame time, we selected25patients who were normal people according to coronaryangiography or coronary CT as a control group, age arrange from47to68years. Theiraverage age were58.44±7.11years. There were17male patients and81female patients.Then we put all patients into four groups according to the different coronary lesions,there were25patients in0disease groups,21patients in1disease groups,27patients in2disease groups,23patients in3disease groups. Collected to the general clinical data ofall patients (age, gender, past history, etc.), and biochemical parameters such as fastingblood glucose (FBG) and blood fat, etc. We collected the blood of all patients in thesecond morning when they haven′t a meal, and detected the level of plasma PTX3byELISA. Then the plasma PTX3level which were fell into different groups werestatisticed by statistical analysis, and we observed the ability of diagnosis acute coronarysyndrome by ROC curve. Finally, plasma PTX3which as dependent variable, andgeneral clinical data、 biochemical data which as independent variables done linecorrelation analysis. All the experimental data use the statistical software SPSS19.0toanalysis when we collected all patient’s information.Results：1.Age、HDL-C and LDL-C of the normal control group had differencesfrom coronary heart disease group (P <0.05), but Age、HDL-C and LDL-C of coronaryheart disease three group was no significant difference (P>0.05)， among the fourgroups of gender, body mass index, history of hypertension, diabetes, smoking,drinking history, TC, TG, UA, blood urea nitrogen, creatinine, systolic blood pressure,diastolic blood pressure, the FBG was no significant difference (P>0.05).2. The plasma PTX3difference of normal control group and SAP group (2.32±0.84,2.91±0.89) was not statistically significant (P>0.05), UAP group (3.76±1.19) andAMI group (3.99±1.29) also was no statistically significant difference (P>0.05).Plasma PTX3of UAP group, AMI group and normal control group (3.76±1.19,3.99±1.29,2.32±0.84) compared a statistically significant difference (P <0.01), the difference of UAP group, AMI group and SAP (2.91±0.89) was statistically significant (P <0.05).3. The area under the ROC curve of plasma PTX3was0.82, and had moresignificant difference with the area under the curve of0.5(P <0.05). Plasma PTX3had acertain degree of accuracy in the diagnosis of acute coronary syndrome, Its sensitivitywas84%, specificity was71.7%, the best cut is3.08ng/ml.4. The plasma PTX3difference of0-vessel coronary artery disease group with1,2,3-vessel coronary artery disease (2.32±0.84,2.96±1.14,3.58±0.81,4.19±1.42)was significant (P <0.05). The plasma PTX3difference of1-vessel coronary arterydisease group with2,3-vessel coronary artery disease (2.96±1.14，3.58±0.81，4.19±1.42) was significant (P <0.05). The plasma PTX3difference of2-vessel coronary arterydisease group with3-vessel coronary artery disease (3.58±0.81,4.19±1.42) wassignificant (P <0.05).5. Plasma PTX3levels was positively correlated with LDL-C, Gensinis integral (r=0.361,0.558, P <0.01), and was not significant linear correlation with other clinical andbiochemical index, such as age, BMI,FBG,TC, TG, HDL-C, urea, uric acid andcreatinine.6. The plasma PTX3which was as dependent variable (Y), and independentvariables of LDL-C, Gensinis Credits(X) which were related to plasma PTX3respectively established regression equation, F value=14.081,42.524, F> F0.01(1,94),P <0.01,so it can be considered that plasma PTX3and LDL-C, Gensinis Credits hadlinear regression relationship.Conclusion：1. Plasma PTX3was connected with the coronary heart disease types,the plasma PTX3of two groups of acute coronary syndrome（UAP group and AMIgroup） was significantly higher than the normal control group and stable anginapectoris, the plasma PTX3of two groups of acute coronary syndrome（UAP group andAMI group）was no significant difference. It prompted that plasma PTX3level may beassociated with unstable plaque rupture，So detected plasma PTX3level may be to helpdetermine plaque is stable. 2. The area under the ROC curve of plasma PTX3was0.82, so the determination ofplasma PTX3level is contribute to the diagnosis of acute coronary syndrome.3. Different lesions count of coronary heart disease and plasma PTX3level hadstatistical difference, and plasma PTX3levels with Gensini Credits were linearregression relationship. So determine plasma PTX3had help to the decide the degreesof coronary vessel, and to provide the theoretical basis for PCI. |
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