The Effects Of Different Doses Of Atorvastatin On Cardiocytes Mitochondria In The Patients With Myocardial Ischemia And Reperfusion Injury

Objective To investigate the impact of mitochondrial function after different dosesof atorvastatin on the ST-segment elevation myocardial infarction in patients with directpercutaneous coronary intervention (PCI) in acute myocardial ischemia reperfusioninjury(MI/RI), and compare two groups of differences biochemical indices and the levelsof cardiac function, to find the best atorvastatin treatment for such patients and explore itsrelated mechanism clinical and laboratory basis. Method120patients who werediagnosed as acute myocardial infarction (AMI) were randomly divided into two groups:20mg atorvastatin group（n=60）and40mg atorvastatin group（n=60）. The patients wereaccepted the PCI treatment in six hours, record the degree of coronary lesions、 TIMIflow grade; to compare the general condition coronary、 angiography and interventionaltreatment results between the two groups; to observe reperfusion injury event situation atimmediately hospitalized、the first day and seventh day after PCI, to observe theconcentration of free fatty acids(FFA), mitochondrial coupling factor-6(CF-6), maleicdialdehyde(MDA), superoxide dismutase-1(SOD-1) and promoting cell apoptosis factorP53; to comprehensive evaluation of atorvastatin after acute MI/RI, the protective effectand mechanism. Results (1)1.There were no statistical significant difference in baselineclinical characteristics and the distribution of coronary artery lesions between two groups.(P>0.05);(2) After postoperative on first day and seventh day the40mg atorvastatingroup’s SOD activity is higher than20mg atorvastatin group;the difference wasstatistically significant (P<0.05), on40mg atorvastatin group the activity of SOD afterpostoperative seventh day is higher than the first day’s, the difference was statisticallysignificant (P <0.05)(3) The concentration of MDA in40mg atorvastatin group is lessthan20mg atorvastatin group after postoperative the seventh day, the difference wasstatistically significant (P<0.05), in both two groups the concentration of MDA afterpostoperative seventh day is lower than the first day, and the difference was statisticallysignificance (P<0.05);(4) The content of FFA after postoperative seventh day is lower than the first day in two groups (P<0.01); The content of FFA in40mg atorvastatin groupis less than20mg atorvastatin group after postoperative seventh day, the difference wasstatistically significance (P<0.05);(5) The CF-6levels in40mg atorvastatin group afterpostoperative seventh day is lower than the20mg atorvastatin group, the difference wasstatistically significant (P<0.05), The content of CF-6after postoperative seventh day islower than the first day in two groups (P<0.05); the difference was statisticallysignificance (P<0.05);(6) The content of P53in40mg atorvastatin group afterpostoperative seventh day is lower than the20mg atorvastatin group, the difference wasstatistically significant (P<0.05); The content of P53after postoperative seventh day islower than the first day in both two groups (P<0.05); the difference was statisticallysignificance (P<0.05);(7) Reperfusion arrhythmias were occurd in both two groups, therate of reperfusion arrhythmias in40mg atorvastatin group is higher than the20mgatorvastatin group (P<0.05);(8) Percentage of TIMI3flow achieved in IRA after PCIbetween the two groups, they had no significant difference(P＞0.05), No-reflow didn’toccur in both grou,two groups90minutes after PCI, ST segment was no statisticallysignificant difference (P>0.05);(9)There were no difference in the rate of myocardialre-infarction, target vessel revascularization,shock and death during hospitalizationbetween two groups.Conclusion Atorvastatin can reduce cytokine, oxygen free radicalformation and reduce cardiac myocyte apoptosis to protect mitochondrial function,thereby relieve the ischemic reperfusion injury in patients who AMI after direct PCI, andthey can improve the patients clinical outcomes in the near future.