Microwave Synthesis Of Fluorescent Quantum Dots For In Vivo And In Vitro Imaging

Quantum dots (QDs) possess unique optical properties, therefore, QDs, which areconsidered as the novel fluorescent probes, have elicited a great deal of attentions in thepast decade. In this thesis, microwave-assissted synthetic strategies are developed forpreparation of fluorescent and water-dispersed quantum dots (QDs), which are furtherutilized for bioimaging applications. The details are as follows:(1) The high quality near-infrared-emitting non-toxic core-shell-shell quantum dots(NIR CSS QDs) are directly synthesized in aqueous phase through a facile one-stepmicrowave-assisted method. Efficient tumor active targeting in live mice was shown byusing the prepared QDs.(2) We present a new microwave-assisted method for one-pot synthesis ofwater-dispersible carbon quantum dots (C-dots). The prepared C-dots are promisingbiological probes for immunofluorescent cellular imaging, in vivo imaging and ink.These researches provided useful evidence for further nano-biological applications ofquantum dots as fluorescent probes.