Synthesis And Charcteristics Research Of Low-molecular-weight Organogel Based On Phenylboronic Acid

A new phenylboronic acid-based gelator was developed in this study,which could interact with several solvents to assemble into athree-dimensional nanofiber network.1H NMR spectroscopy studysuggests that the driving force for the gelation includes hydrogen bondingand π-π stacking. Evaluated by UV-spectroscopy, the gel showed aprompt initial response to glucose even at low concentration of2.1mg/mL, which is a critical concentration of venous plasma glucose fordiabetes). Significantly, this organogel exhibits excellent sensitivity toglucose among seven sugars tested (i.e., mannitol, galactose, lactose,maltose, sucrose and fructose). The proposed formation ofhydrogen-bonded complexes during the glucose sensing was supportedby our energy calculation. Meanwhile this organogel exhibits strongpH-response for the pH above11to13. Importantly, this gel could beconveniently recycled and thus be reused.In order to explore more low-toxicity gelation solvents for the gelators,further study on the preparation and properties of organogel based oncyclodextrin inclusion of gelator was carried out. The low moleculargelator inclusion of β-cyclodextran were prepared to have the transparentgel in ethanol. A three-dimensional nanofiber network was exhibited inthe organogel. The effects of temperature, salt on the stability of gel werealso explored. The results suggested that the gel was more stable at lowertemperature. The addition of salts could improve the stability of gel from2.5h to45h.