Flavored Small Bitter Xinshang Dialectical Add And Subtract Treatment Of 22 Cases Of Clinical Research Occlusive Bronchiolitis In Children

Bronchiolitis Obliterans in children is a relatively uncommon chronic airflow obstruction syndrome related to small airway inflammatory injury, which leads to the pathological features of irreversibility the bronchioles and surrounding inflammation and fibrosis in lumen partial or complete occlusion. Its main clinical manifestations are repeated or persistent shortness of breath and wheeze or cough, poor exercise tolerance, auscultation of the lungs for wheezes and crackles, resistance to bronchodilator, pulmonary high-resolution CT (HRCT) features of Mosaic perfusion sign. The treatment outcome of childhood bronchiolitis obliterans is uncertain,and overall childhood postinfectious bronchiolitis obliterans would have poor long-term outcome. A prospective study of BO in children found that9.7%of BO children had died in3.5years,67.7%of BO children respiratory signs and symptoms persisted. There has not yet formed a unified childhood BO syndrome diagnosis of traditional Chinese medicine(TCM) curative effect standard and breathing control criteria. As increasing clinical reports about BO in children, pediatrics of traditional Chinese medicine scholars also pay close attention, and put forward their own theories.Objective:to observe the clinical curative effect of Jiawei Xiaokuxin Tang applied by professors Xu Rongqian to treat bronchiolitis obliterans in children, and to investigate the etiology and pathogenesis, therapeutic principle and treatment.Methods:referring to the diagnosis of disease and curative effect of TCM pediatrics disease syndrome diagnostic criteria of TCM standards issued by the state administration in1995and the asthma control test criteria, drew up the childhood BO clinical effect table by the treatment of Jiawei Xiaokuxin Tang and the evaluation criteria of curative effect, wheeze test control assessment table of childhood BO and evaluation criteria. Each BO case had more than3months treatment.And then compared results of tables between prior treatment and post-treatment, discussed that clinical effect of Jiawei Xiaokuxin Tang.Results:there was significant difference between prior treatment and post-treatment results of22BO cases with the treatment by Jiawei Xiaokuxin Tang in clinical effect tables and wheeze test control assessment tables. Of22BO cases, the wheeze test control assessment resluts were7cases (31.8%) with positive control,12cases (54.5%) with good control,3cases (13.6%) with poor control.The total effective rate of22BO cases after more than3months was86.4%(19cases), thereinto, the significant effective rate was50%(11cases),the effective rate was36.4%(8cases), inefficient rate was13.6%(3cases),Clinical recovery rate was0(0cases).Conclution:the pathogenesis of childhood BO is thought that the deficiency of vital qi and stagnation of qi might be its pathogenesis by professors Xu Rongqian,who treat the acute phase BO in children,using Jiawei Xiaokuxin Tang and according to Xinkaikujiang Ditankaibi principle.