With Astragalus Membranaceus Double Leaf Particles Adjuvant Treatment Of Iga Nephropathy (qi And Yin Deficiency Syndrome) Is A Randomized Controlled Trial

In China, Primary glomerular disease is the main reason for ESRD (End-stage of renal disease), and IgA nephropathy (IgAN) accounts for the largest proportion by the percent of40to47.2%. Also,26.29percent of People with ESRD were developed from IgAN. So, we can see that IgAN is the material cause of ESRD. There are many pathological styles of IgAN, but the most commonly clinical symptoms are hematuresis and hematuresis accompanied with proteinuria. However, Its far from satisfying about treatment effects of IgAN by now. In clinical, most IgANs are induced by Cold or Pharyngitis, and are accompanied by symptoms that easily to relapse, such as catching a cold, chronic Pharyngitis, Antiadoncus, mouth ulcer, diarrhea or piss discomfort. This topic is expected to improve the aforementioned symptoms, reduce the relapsing frequency, control the progress of the disease and reduce the risk of evolving into ESRD by using the method of dietetic therapy of traditional Chinese Medicine (Huangqishuangye Granule).Objective:Through clinical randomized controlled trials, assess clinical efficacy of TCM dietetic therapeutic side of Huangqishuangye Granule on IgA nephropathy (syndrome of deficiency of Qi and Yin), and provide scientific basis for the traditional Chinese dietetic therapy in treatment of IgA nephropathy. To observe the effect of Huangqishuangye Granule on IgA nephropathy patients (syndrome of deficiency of Qi and Yin), the changes of24hour urine protein quantitation, urine red blood cell count, TCM syndrome score, the safety effect of Huangqishuangye Granule on IgA nephropathy patients (syndrome of deficiency of Qi and Yin).Methods:A randomized controlled trial with total study time for about half a year.60patients tthat in accordance with Qi and yin deficiency of IgA nephropathy will be recruited, then the60patients will be divided into the dietetic therapy group and control group randomly. The control group will receive basic therapy, including low salt low fat diet and Blood Pressure-Lowering, and the dietetic therapy Group will receive Huangqishuangye Granule on the basis of foundation treatment. All enrolled patients will receive blood routine test, urine analysis,24hour urinary protein quantitation, liver and kidney function, blood lipids. TCM syndrome score evaluation,and investigation of mucosa associated symptoms. Blood routine test, liver and kidney function, and blood lipid will test a second test in the end of the experiment,and urine analysis,24hour urinary protein quantitation will get a second test of every8weeks. Also.we need to evaluate TCM syndrome symptomatic scores of every8weeks, investigate mucosa associated symptoms of every8weeks.and then carry on the statistical analysis of the above data in the end of the experiment.Results:A total of60patients, the treatment group and the control group have30case in each group, patients have no significant differences with baseline data, the main observation index, TCM syndrome score and mucosa associated symptoms. At the end of the experiment, compared with that before treatment the treatment group has significant differences of decrease by the aspects of24hour urinary protein quantitation, urine red blood cell count, TCM syndrome score,and mucosa associated symptoms. However,the control group shows rising trend of24hour urinary protein quantitation, urine red blood cell count, TCM syndrome score,and mucosa associated symptoms.All above results indicate that Huangqishuangye Granule has good curative effect for IgA nephropathy(syndrome of deficiency of Qi and Yin).As a chronic progressive disease, hematuria, proteinuria will gradually aggravate without effective intervention measures.Conclusions:Huangqishuangye Granule has good curative effect for IgA nephropathy(syndrome of deficiency of Qi and Yin), and can reduce24hour urinary protein quantitation, urine red blood cell count, TCM syndrome score and mucosa associated symptoms. It shows that dietetic therapy of traditional Chinese medicine can improve the patient’s constitution, control harmful factors, reduce the recurrent hematuria and proteinuria, and block the persistent and development course, which is conducive to the protection of renal function, so as to improve the prognosis of patients with IgA nephropathy.