108 Cases Of Metabolic Syndrome Of Tcm Syndrome Type And The Correlation Of Carotid Intima-media Thickness

Objective:To study the relationship between different TCM syndrome of metabolic syndrome and carotid intima-media thickness, and to explore the correlation between different TCM syndrome of metabolic syndrome and its components, and to discuss the factors of influencing carotid intima-media thickness,further clarify the TCM syndrome type of metabolic syndrome and related etiology and pathogenesis, to provide an objective basis for TCM syndrome of metabolic syndrome and prevention and treatment of cardiovascular and cerebrovascular diseases and diabetic macroangiopathy.Method:Based on the research of the inclusion and exclusion criteria,108patients of metabolic syndrome were collected from2012January to2013January in Department of traditional Chinese medicine of Beijing Hospital,according to 《the guiding principle of clinical research on new drugs of Chinese medicine》 and ((national standard of the people’s Republic of China》,the patients of metabolic syndrome with four TCM syndromes of both qi and Yin deficiency, Yin deficiency and dryness-heat, phlegm wet resistance and phlegm blood stasis blocking collaterals.Collect the general condition and clinical data, and use statistical methods to compare the relationship between four different syndrome types and carotid intima-media thickness,blood glucose, blood pressure,blood lipids, and to find out the influence factors of carotid intima-media thickness.Results:1IN108patients of metabolic syndrome，there are5patients under the age of45,31patients under the age of45～59,39patients under the age of60～74,33patients under the age of74～89,no older than90.The number of male patient is66, and other42patients are female. Merging fatty liver,74cases (68.5%)， merging coronary heart disease26cases (24.1%), merging cerebrovascular disease in25cases (23.1%).2The TCM syndrome of metabolic syndrome composition:phlegm blood stasis blocking collaterals group (33cases)> both qi and Yin deficiency group (30cases)> phlegm wet resistance group (23cases)> Yin deficiency and dryness-heat group (22cases).3BMI comparison of different TCM syndrome types of MS:the phlegm wet resistance> phlegm blood stasis blocking collaterals group> Yin deficiency and dryness-heat group> qi and Yin deficiency, qi and Yin deficiency group is different from phlegm wet resistance groups and phlegm blood stasis blocking collaterals group (P<0.05).4Comparison of carotid intima-media thickness between different TCM syndrome type of MS:qi and Yin deficiency group=phlegm blood stasis blocking collaterals group Yin deficiency and dryness-heat group>phlegm wet resistance; Different TCM syndrome types of maximum carotid intima-media thickness: qi and Yin deficiency group> phlegm wet resistance group> phlegm blood stasis blocking collaterals group> Yin deficiency and dryness-heat, Yin deficiency and dryness-heal group is different between qi and Yin deficiency and phlegm wet resistance group (P<0.05).5Metabolic syndrome TCM syndrome type of diabetes duration comparison:qi and Yin deficiency group>phlegm blood stasis blocking collaterals group>phiegm wet resistance> in deficiency and dryness-heat group, Yin deficiency of heat is different from phlegm blood stasis blocking collaterals group (P<0.05).6Metabolic syndrome of traditional Chinese medicine syndrome of hypertension course comparison: phlegm blood stasis blocking collaterals group>phlegm wet resistance group>both qi and Yin deficiency group>Yin deficiency and dryness-heat, there are differences between phlegm blood stasis blocking collaterals group and Yin deficiency and dryness-heat group, phlegm blood stasis blocking collaterals group and phlegm wet resistance (P<0.05), there is no obvious difference between others (P>0.05).7Comparison of HbA Ic:Yin deficiency and dryness-heat group> phlegm wet resistance group> phlegm blood stasis blocking collaterals group> qi and Yin deficiency, Between qi and Yin deficiency group and Yin deficiency and dryness-heat group or phlegm wet resistance group there are differences (P<0.05).8According to the carotid artery intima-media thickening with no packet, carotid artery intima-media thickness and combinations of20cases of coronary heart disease (25.6%),24cases with cerebral vascular diseases (30.8%), was higher than that of carotid artery intima-media of normal group, but there were no significant differences between the two groups (P>0.05). In the two groups in the presence of lower limb artery stenosis and lower limb atherosclerosis, diabetes, and hypertension duration time have differences, TG,HDL-C(P<0.05).9According to different duration of diabetes and hypertension.the patients of MS were divided into3groups;<5years,5-10years and>10years, three groups with different course in the carotid artery and lower extremity artery plaque (P<0.05) are different, and different duration of hypertension group is also different in carotid artery plaque (P<0.05).Conclusion:1Phlegm blood stasis blocking collaterals type is very common on TCM syndrome of metabolic syndrome.2Different TCM syndrome types of metabolic syndrome and carotid artery intima-media thickness has some relevance, the carotid intima-media thickness between different TCM syndrome types of metabolic syndrome are different,the degree of carotid artery intima-media thickness in qi and Yin deficiency type is the largest.3The BMI, hypertension and diabetes duration, HbA1c between different TCM syndrome types of metabolic syndrome are different。4The carotid artery intima-media thickness and the metabolic syndrome in patients with diabetes and hypertension duration, TG, HDL-C has a certain relationship. And the carotid artery and lower extremity arterial plaque with diabetes and hypertension have a certain relationship, the duration is longer, the occurrence frequency of carotid artery and lower extremity arterial plaque is more.