Based On The Modern Basis To Explore Maxingshi Gan Decoction Syndrome Rule

Ma Xing Shi Gan decoction as one of the Chinese classical decoctions is praised by its rigorous combination and remarkable curative effect. Modifications of the formula have been widely applied to treat various diseases by practitioners of later generations, such as pneumonia, chronic bronchitis, bronchial asthma, intractable cough, nasosinusitis, acute Incarcerated hemorrhoid, and aphonia and so forth. After sorting out the clinical medical records related to Ma Xing Shi Gan decoction in recent years, the article is going to analyze its application regularity in modern clinic by Excel spreadsheet and statistics aiming at providing new approach for its standardization research.ObjectiveFirst of all, to establish the database of clinical applications of Ma Xing Shi Gan decoction, and summarize its formula pattern characteristics in the process of clinical application including geographical distribution of diseases, seasonal distribution, classification of diseases, gender, age, traditional Chinese and western medicine diagnosis, syndrome type, symptom, tongue, pulse, and modification of Chinese herbs. Secondly, to sum up the characters of dosage in its clinical application by data mining technology, this mainly focuses on dosage analysis of single herb and analysis of influencing factors on dosage. Finally, to provide reference for standardized application of Ma Xing Shi Gan decoction based on the statistical results.Contents and MethodsTaking Ma Xing Shi Gan decoction as subject term to search for related literatures recording medical cases treated by Ma Xing Shi Gan decoction from China national knowledge internet (CNKI), wanfang data knowledge service platform (WFKS), and China scientific journal database published from1979to2012. Besides, the relevant journals of traditional Chinese medicine published ranging from1949to1978were also collected and summarized.Effective information of the selected literatures were recorded into Excel spreadsheet. The clinical application of Ma Xing Shi Gan decoction was analyzed by statistics. Results1. The clinical application of Ma Xing Shi Gan decoction displayed obvious difference in geographical distribution. The most frequency of usage was in East China (N=101), accounting for30%. The Central China, and North China took the second place. The least frequency of usage in Northeast China (N=15), only accounting for4%. The clinical application of Ma Xing Shi Gan decoction was mainly in winter and spring. There were no significant differences in gender.2. Formula pattern characteristics:Diseases treated by Ma Xing Shi Gan decoction principally related to respiratory system. Among359medical cases, of which251belong to respiratory system, accounting for about70%. The main syndromes of diseases covered21nomenclatures of disease in TCM. The panting pattern was involved most, accounting for26.7%, and cough took the second place, accounting for17.6%. The rest also frequently occurred were measles, wheezing pattern, bi yuan (sinusitis), enuresis, edema, and hemorrhoids. The nomenclatures of western diseases were involved were28. The pneumonia was in the first, with the percentage of22.8, then bronchitis11.7%. The remaining frequently occurred were asthma, emphysema and nasosinusitis, and urticaria. The main symptoms were presented with cough (75.5%), fever (63.2%), and expectation of phlegm (57.1%), which the frequencies of usage were all over50%. In addition, panting, dry mouth, shortness of breath, running nose, sweating, edema, poor digestion, chest depression, and constipation also always occurred. The most frequent tongue coating was red tongue and yellowish tongue coating. Pulse most frequently took was rapid, accounting for65.2%, the rest were slippery, superficial, wiry, and thready.3. Characteristics of dosage:According to data analysis, the minimum dosage, maximum, average, and dosage range of common usage of the Herba Ephedrae (ma huang, ephedra herb), Semen Armeniacae Amarum (xing ren, almond), Gypsum Fibrosum (shi gao, gypsum), and Radix ct Rhizoma Glycyrrhizae (gan cao, liquorice root) were0.3g,40g,6.3g, and3-10g;2g,20g,9.1g, and6-12g;1g,120g,25.3g, and15-30g;1g,30g,5.8g, and3-9g respectively. The three herbs of Herba Ephedrae, Semen Armeniacae Amarum, and Radix et Rhizoma Glycyrrhizae were used in larger dosage in Northeast China compared with other regions and Gypsum Fibrosum was used in Southeast China in larger dosage in comparison of other places. Dosages of Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, and Radix et Rhizoma Glycyrrhizae were higher in autumn than those in the other three seasons. The average dosage of each in child was approximately1/3of that in adult. On treating panting by Ma Xing Shi Gan decoction in clinic, the dosage of Herba Ephedrae was much higher, while treating sinusitis, GypsumFibrosum’s dosage was higher. The commonly seen ratio of Herba Ephedrae and Gypsum Fibrosum was1:5or1:3. The most frequent added herb in clinical prescriptions was Radix Scutellariae (huang qin, scutellaria root), accounting for33.1%. The second and third ones’were Radix Platycodonis (jie geng, platycodon root)(22.6%) and Semen Lepidii (ting li zi, pepperweed seed)(21.7%). The applied frequency of these three herbs was over20%. The other added herbs included Fructus Forsythiae (lian qiao, weeping forsythia capsule), Cortex Mori (sang bai pi, white mulberry root-bark), Rhizoma Pinelliae (ban xia, pinellia rhizome), Fructus Trichosanthis (gua lou, snakegourd fruit), Flos Lonicerae Japonicae (jin yin hua, honeysuckle flower), Herba Houttuyniae (yu xing cao, heartleaf houttuynia herb), and Fructus Perillae (su zi, perilla fruit), with application frequency all over10%.