Flavored Definite Particle Improved Appetite Of Tumor Patients Clinical Curative Effect And Mechanism Research

Background:Tumor associated anorexia limits the diet of patients with cancer, affects their nutritional status, lowers immunity, increases the risk of infection, improves cachexia course, which has become one of the factors on impacting cancer patients quality of life. As the idea of improving the cancer patients’quality o life gradually thorough, the clinical no longer simply pursuits prolong survival, but focuses on how to improve the quality of life.The importance of treatment of cancerous anorexia is particularly prominent. At president, megestrol acetate is relatively mature in treatment of carcinoma of anorexia. But it has side effects such as water retention, venous thrombosis, which limits the clinical use. Traditional Chinese medicine has high security and good clinical curative, which makes the patients easy to accept. As the effective components of traditional Chinese medicine and traditional Chinese medicine injection development, traditional Chinese medicine in the treatment of tumor associated anorexia has a huge advantage and broad prospects. But for now, medicine for treatment of anorexia is not going to meet the demand of clinical, the pathogenesis of tumor associated anorexia is not clear, and lacking convenient and effective clinical evaluation of degree of scale on tumor associated anorexia. Based on the above, we innovatively use appetite NRS score for quantitative analysis and evaluation appetite. To observe the effect of jiaweizhizhu particles on appetite and the quality of life for cancer patients,and improve the appetite NRS score.Using enzyme-linked immunoassay detection of Orexin and leptin to explaine the relationship with tumor associated anorexia, and explore the pathogenesis of tumor associated anorexia from molecular level. To provide clinical evidence for traditional Chinese medicine in improving appetite and quality of life for patients with tumorPurpose:To observe jiaweizhizhu particle’s effect on tumor patients appetite and quality of life, and explore the pathogenesis of tumor associated anorexia.Methods:This subject adopts randomized controlled clinical research method, using appetite NRS score, KPS score, leptin, orexin as observation index.120cases are from Beijing university of Chinese medicine dongzhimen hospital who are hospitaled during2011.1to2012.10with anorexia patients,ane they are randomly divided into treatment group60cases (jiaweizhizhu particle group) and control group60cases (megestrol acetate group),90cases into the statistical analysis of cases,58cases in treatment group,57cases in the control group. All cases are treatmentde for4weeks, in the0week,2week,4weeks monitoring the evaluation indexesUsing SPSS13.0software to statistics:count data use chi-square test for statistical analysis,measurement data to mean+/-standard deviation(x±s).Measurement data,which meets normal distribution before and after the treatment, use paired t test. If it does not meet normal distribution, use two related samples nonparametric tests.Comparison between groups with homogeneity test of variances and One-Way ANOVA analysis program. There is statistical significance (P<0.05) said. Result:The results show that:1.Appetite NRS score:Treatment group and control group all can reduce appetite NRS score, increase appetite. Improved effect is better for patients with mild, moderate, anorexia, patients with severe effect is poorer.After4weeks, treatment group total effectiveness is67%, mild effective rate is69%; Moderate effective rate is72%; Severe efficient is20%. The control group total effective rate is65%, mild effective rate is64%; Moderate effective rate is69%; Severe efficient is25%. Comparison between the two groups:the total effective rate is P=0.85>0.05, mild anorexia is P=0.698>0.05, moderate anorexia is P=0.712>0.05, severe anorexia is P=0.702>0.05, which all has no statistical significance.2. KPS score:on the2th week, treatment group and control group’s effectiveness is respectively50%,57%; on the4th week, treatment group and control group efficient is respectively74%,72%. P>0.05, which has no statistical significance.3.Leptin:Treatment group before treatment,the2th week, the4th week treatment, leptin values respectively is3.60±0.91、3.12±0.79、2.70±0.67; comparison in intra-group, P<0.05, has statistical significance. Control group before treatment,the2th week, the4th week treatment, leptin values respectively is3.84±0.97、3.37±0.81、2.92±0.74; comparison in intra-group, P<0.05, has statistical significance. But the comparison between the inter-group, on the2th week orthe4th week, P>0.05, has no statistical significance.4.Orexin:Treatment group before treatment,the2th week, the4th week treatment,orexin values respectively is7.66±1.68、8.76±1.73、9.87±1.82; comparison in intra-group, P<0.05, has statistical significance. Control group before treatment,the2th week, the4th week treatment, orexin values respectively is7.30±1.53、8.44±1.61、9.57±1.72; comparison in intra-group, P<0.05, has statistical significance. But the comparison between the inter-group, on the2th week or the4th week, P>0.05, has no statistical significance.Conclusions:Jiaweizhizhu particles can improve malignant tumor patients’appetite and quality of life, orexin、leptin participated in the formation of tumor associated anorexia.