| Objective:Through applying the clinical pathway of Artery sclerosis obliterans (not collapse period) in the diagnosis and treatment of blood stasis type of ASO, we make a comparison between the treatment group and the control group in the situation of cold, dorsalis pedis artery pulsation, claudication distance, skin nutritional status, ABIto prove the efficiency of the clinical path way. At the same time, by detecting CRP levels and platelet aggregation function, we preliminarily discuss the mechanism of Traditional Chinese medicine for activating blood circulation to cure Artery sclerosis obliterans.Methods:There are63patients who meet the criterion of arteriosclerosis obliterans in blood stasis resistance have been included in this study. And they have been divided into two groups. On the basis of conventional treatment and aftercare, the treatment group used peach siwu tonga subtraction, at the same time taking aspirin. The control group only used aspirin. After7days and14days treatment, the curative effect with reference to criteria, through integral change we observed two groups of patients with clinical symptoms, signs of change. We used the data statistics and analysis to compare two different methods in treating blood stasis resistance model to evaluate the clinical efficacy of arteriosclerosis occlusion disease. And before and after treatment we detected CRP level and platelet aggregation function to analyze and compare.Results:First course compared with before treatment in the treatment group, The aspects of cold feeling, intermittent claudication distance, ABI much significantly improved than before treatment (P＜0.05). There is statistically significant. The second treatment compared with before treatment, two groups in the aspects of cold feeling, intermittent claudication distance, dorsalis pedis pulses, ABI, CRP levels and platelet aggregation function improved significantly, P＜0.05. And the skin nutrition improvement is not obvious (P＞0.05), no statistical significance.At the end of the first course, between the treatment group and the control group, the indicators of the skin nutrition, dorsalis pedis artery pulse, ABI (P＞0.05) had no statistical significance. AT the aspects of cold feeling and intermittent claudication distance, the treatment group is superior to the control group (P＜0.05). CRP levels in the treatment group much more decreased than the control group (P＜0.05). AT the aspect of platelet aggregation had no statistical significance (P＞0.05). At the end of the second course, between the treatment group and the control group, the indicators of skin nutrition had no statistical significance. At the aspect of cold feeling, intermittent claudication distance, dorsalis pedis pulses, ABI, the treatment group is superior to the control group (P＜0.05).CRP levels in the treatment group much more decreased than the control group (P＜0.05). AT the aspect of platelet aggregation had no statistical significance (P＞0.05).At the end of the first course Chinese medicine, the treatment group in CRP levels were obviously improved (P＜0.05). The control group has not the obvious effect on CRP (P＞0.05).; At the end of the second course of treatment, the treatment group and the control group in CRP were both obviously improved (P＜0.05). Comparison between the two groups, the treatment group is superior to the control group (P＜0.05) in each node of the CRP improvements.At the end of the first course Chinese medicine, the treatment group and the control group in improving the platelet aggregation function were not seen obvious effect (P＞0.05), no statistical significance. At the second end of the course, the treatment group and the control group in improving the function of platelet aggregation both had obvious effect (P＜0.05), significant statistical significance. Comparison between the two way, the treatment group and the control group in terms of each node in the platelet aggregation function group had no significant difference,(P＞0.05), no statistical significance.Conclusion:The treatment group for activating blood circulation (peach siwu tonga subtraction) in the treatment of blood stasis blocking type hardening of the arteries occlusion disease has good curative effect. The rate of otal effective is better than the control group. The treatment group can quickly improve symptoms and signs, shorten period of treatment, relieve the suffering of the patient. The treatment group can reduce inflammatory response earlier, the serum CRP level and the inflammatory response. Arteriosclerosis occlusion disorder (without collapse) clinical pathway has the advantage from diagnosing and treatment to nurse daily. That has formed a complete set of treatment and can provide better service for patients, solve the pain, improve curative effect. |
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