Pepsi Music Capsule On Chronic Stress Depression Model In Mouse Model Ngf And Bdnf

Objective To investgate the effects of Baishile capsules on the behaviors and brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in mice with chronic stress model of depression.Method64male mice were randomly divided into healthy group,model group,Baishile capsules group and fluoxetine froup.Except the health group,others were cxposed to chronic stress with21days for model. All the mice in treated group were respectively given corresponding medicines before modeling.While the model group weere given the same volume of distilled water.Body weight of mice were measured, behavioral changes were tested by open field experiment and the immobility time in tail suspension experiment.the contents of BDNF and NGF of mice were tested by immunohistochemical method.Result Obvious behavioral changes were found in model group,including the reduce of horizontal and vertical activities and the prolong of tail suspension immobility time.compared with the model group,the body weight of mice in Baishile capsule group. Compared with the model group,the body weights group were significantly increased(P<0.05)and the behavioral parameters were improved remakably(P<0.001). It can also improve the amount of BDNF and NGF. Compared with fluoxetine froup,every indicators in Baishile capsule group had no significant differences (P>0.05)Conclusion Baishile capsule can significantly improve the behavior changes of chronic stress mice.Its effect may be related to the amount of BDNF and NGF caused by incresing chronic stress.