Tonic Mist Method Of Clinical Curative Effect Evaluation Research For The Treatment Of Postpartum Depression

Background:Postpartum Depression(PPD) is one form of depression, which refers to the depressive symptoms during puerperium, mainly emerge in the first two weeks after labor, with obviously symptoms in the4th to6th week, duration can be3-6months. Incidence of PPD in other countries is approximately11%-23.25%. With such a high incidence, PPD not only affects matenals’health, but also endanger infants, family, bringing heavy burden to family and society. The current treatment to PPD, western medical approaches mainly include drug treatment and psychological treatment. Drug treatment is expensive and it also has side-effects and lactation feed issues. For psychological treatment, it needs choice and adjustment timely according to the patients’psychological situation, with poor controllability and consistency. In recent years, as the incidence of PPD increased year by year, Traditional Chinese Medicine treatment achieve certain effect on PPD’s research, Traditional Chinese Medicine has distinct advantages in efficacy and safety, likely to be accepted by patients. But Traditional Chinese Medicine treatment lack of a unified understanding for PPD treatment, and PPD’s self-healing feature, most researches had not set placebo group, comparing with western medicine directly, lacking of rigor. So to select postnatal patients with depression of heart and spleen deficiency syndrome as objects of study, conduct random, comparative, double-blind clinical research has certain significance and value.Purpose:Take60postnatal patients with depression of heart and spleen deficiency syndrome who meet the standards as objects of study, conduct random, comparative, double-blind clinical research. Complete Traditional Chinese Medical treatment’s clinical evaluation and safety analysis for PPD, further clarify Traditional Chinese Medical treatment’s efficacy, advantages, safety and range of treatment for PPD.Methods:All the PPD patients in this research from Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine and three subordinate communities from January2011to March2012. This research observed total60postnatal patients with depression of heart and spleen deficiency syndrome, set30cases in treatment group and30cases in placebo group. Patients in treatment group took Shenqijieyu Particles1dose/day. Patients in placebo group took Starch Particles1dose/day. Both group adopted6weeks’treatment. Distributed in before treatment,1st week,2nd week,4th week,6th week after treatment, used in Edinburgh Postnatal Depression Scale, EPDS and TCM Depression Scale to evaluate the efficacy, measure the serum estradiol and progesterone levels before and after treatment.Results: 1EPDS deducted rate Clinical efficacy evaluation:in the6weeks’treatment. The total effective rate in treatment group was86.67%, with26.67%Clinical control rate. The total effective rate in placebo group was70.00%, with0%Clinical control rate; EPDS deducted rate difference in2group’s2nd week,4th week,6th week’s treatment was statistically significant(P<0.05).2Use TCM therapeutic index clinical efficacy:The total effective rate in treatment group was86.67%, with26.67%Clinical control rate. The total effective rate in placebo group was70.00%, with10%Clinical control rate. Traditional Chinese Medical syndrome deducted rate in2group’s2nd week,4th week,6th week’s treatment was statistically significant(P<0.05).3Both treatment group and placebo group have shown upward trend in estradiol levels, after6weeks’treatment, the difference between treatment group, placebo group and Self-healing was statistically significant(P<0.05).4Both treatment group and placebo group shown downward trend in serum progesterone levels, after6weeks’treatment, the difference between treatment group, placebo group and Self-healing was statistically significant(P<0.05). Level rised Contradistinction between treatment group, placebo group and Self-healing has no statistically significant (P>0.05)Conclusion:1. Clinical assessment of postpartum depression with heart and spleen method treatment60patients who conform to the standard with random, comparative, double-blind research. Compare the differences in efficacy of Shenqijieyu Particles and placebo treat to postpartum depression of heart and spleen deficiency syndrome. The results show that Shenqijieyu Particles treatment group’s efficacy better than placebo group’s. To further defined the efficacy, advantages and security of Chinese Medical treatment of postpartum depression.2. Discusses the mechanism of Chinese Medical interventions for postpartum depressionDetected estrogen and progesterone level in patients’serum before and after treatment. To further explain the mechanism of Shenqijieyu Particles treat to postpartum depression, the research shows that Shenqijieyu Particles could improve estradiol level of postpartum depression of heart and spleen deficiency syndrome, and further enrich the theory of Traditional Chinese Medicine for postpartum depression and clinical contents.3. Shenqijieyu Particles treatment in postpartum depression has better clinical efficacy, less side effects and higher compliance. The particle has obvious advantage, it is a more safe and effective Chinese Medicine formula.