| BackgroudThe most commonly seen malignant tumor in the world, gastric cancer refuse to the malignant tumor arising from gastric epithelial tissue, whose mortality rate accounts for23.02%of all death from malignant tumor, which ranks first among all malignant tumor. Gastric cancer is usually in advanced stage at diagnosis, without opportunity for curative resection. Characterized by evolving insidiously, the radical surgery rate of gastric cancer account only35%, the-5year survival rate at patients after radical surgery is only50-60%.Therefore seeking more effective treatment methods is becoming a more urgent problem. Guided by Traditional Chinese medicine theories, based upon professor Xin Yi-Chen’s academic idea regarding diagnosis and treatment of gastric cancer.The first part of the thesis concerns study in theory; it summarizes the etiology and pathogenesis study of gastric cancer with literatures in contemporary medical. Another, views ancient TCM literatures regarding gastric cancer, the point of views on the name, analyzes the etiology and pathogenesis of advanced gastric cancer and discusses the differentiation and treatment methods through incorporating ancient TCM theories with modern medical researches.Gastric cancer is usually in advanced stage at diagnosis, without opportunity for curative resection. Chemotherapy is the major treatment for advanced gastric cancer(AGC), and other treatments include palliative surgery, radiotherapy, chemotherapy, biologic and immunologic therapy as well as Chinese medicine. Palliative therapy is used to reduce tumor load or complication occurrence, while radiotherapy is effective for regionally advanced gastric cancer, At present, chemotherapy plays a leading role in AGC treatment and has a palliative effect on symptomatic patients. For advanced or metastatic gastric cancer, chemotherapy has always been the focus of studies.. Biologic and immunologic therapy are beneficial supplements to surgery, chemotherapy and radiotherapy. All of these treatments have obvious side effects. Other comprehensive methods are of equal importance, such as Chinese herbal medicine, acupuncture and moxibustion psychological intervention. Combined with Western medicine, the above methods have certain merits in relieving clinical symptoms, reducing toxicity, increasing effectiveness, improving quality of life.Part two is summarized professor Xin Yi-Chen’s academic idea regarding diagnosis and treatment of gastric cancer and report the clinical demonstration of Xinjialiangfu。 This study indicated that Xinjialiangfu can inhibit tumor cell growth both in vivo and vitro and nduce tumor cellapoptosis, which can predict Xinjialiangfu has a wide application prospect in cancer treatment. |
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