Based On The Literature Of Migraine Pro Scale Comparative Study

Objective1. Summarize the present evaluation methods on migraine Home and abroadMigraine is a kind of disease taking the patients’subjective discomfort as the main performance.It has great influence to the quality of life of patients, and it can make patients labor fell rapidly which can cause serious economic, physiological and psychological burden. For such a disease, the treatment effect is of concern for the patients and doctors, so making a standard of the methods of outcomes assessment is very necessary. But in migraine clinical research at home and abroad, there is no scientific and normative system of curative effective evaluation methods. The author search for the articles about the migraine treatment in clinical research at home and abroad in recent ten years, screen, summary,and classify the curative effect of evaluation methods, to find the system for migraine evaluation method of curative effect.2. Compare the migraine PRO scale with other PRO scales on literatureOur research group has already successfully developed the Migraine PRO Scale. In order to improve the content and take the evaluation futher more, this article compare the Migraine PRO Scale with all the domestic existing PRO scale. Through analying the differences in PRO scale content and evaluation methods, we draw lessons from them for migraine PRO scale, to facilitate the next step of the scale improvement and further evaluation.Research methodSearch out literatures about Migraine from January1990to December2011in CNKI Chinese academic literature network edition database and PubMed, respectively taking "偏头痛治疗","Migraine treatment" for the subject or keywords. Then select the methods to evaluate the clinical efficacy, and make them classified and summarized.With "PRO scale, patients report end, PRO evaluation, PRO evaluation, PRO assessment" as the theme, we searched for the academic literature in CNKI Chinese academic literature network edition database. We combined the articles on the same scale, distinguish different quantity survey evaluation literature on the same scale, wipe off articles without detailed description of formulation, then we summed up contents, structure and the evaluation method.Result Migraine is characterized by remission and relapse, with pain as the main symptoms of the recurrence-of-ease diseases, at present the curative effect of migraine focused on headache attacks, such as headache time, headache frequencies, headache ease time, etc. It has not been reflected in symptoms of the mental change and function damage, and the current examination, assay index can not directly and fully reflect the patients with migraine headache and curative effect. The domestic and foreign migraine evaluation seals are divided into two aspects, of life quality, and headache influence and disability, or borrowing pain assessment scales. The specific degree is not good enough and sensitivity is not quite high. None of them can generalize all aspects of the impact. As one of scale marked by the patients, PRO scale is more and more emphased by people at present. Also because most migraineurs take all kinds of discomfort as their subjective feeling, PRO scale effect assessment of migraine has important significance.PRO scale can be separated into two parts of the structure of population, general information and scale text. In the statistic of general population information, most researchs are according to the disease characteristics and the content and evaluation disease in design.Through the statistical of36studies on the main body of the scale terms, we can sum up the scale structure term as:entries/variable/item-field/subdomain-domain/dimension, and according to the clinical acceptance of high and low, combined with the draft guidelines issued by the food and drug administration (FDA) applied to clinical effect assessment and the drug development in the PRO study, we suggested the item-field-domain term structure to be used. Migraine PRO scale are standard in the content and structure.PRO scale evaluation methods are roughly the same, but the classification of methods is not very united. PRO scale can basically evaluated from the reliability and validity, reaction degree, feasibility evaluation, etc.To evaluate the reliability, according to frequency of high and low, they can be divided into Cronbach’s αcoefficient, half the reliability and the test-retest reliability. Simple and complex correlation coefficient matrix related reference is usd less. Cronbach’s α coefficient and half the reliability and can also be called internal consistency reliability,while test-retest reliability can also be called as the external reliability. Validity can be divided into content validity, contract val idity, criterion-related validity, discriminant validity, correlation analysis and regression analysis. Reaction can be devided into the ability distinguishing different crowda and distinguishing different time of the same people crowd. Feasibility is usually evaluated by scale accept rate, completion rate, and completion time. Accept and accomplish rate are usually required to be above85%. Finish time usually should be controlled in20minutes or less. In addition to the evaluation methods above, the less application of the methods are differentiate, project item response theory, covariance analysis, etc.Through the half reliability and Cronbach’s aevaluation,we can prove the rel iability of Migraine PRO scale is good, and from the content validity, standard validity and structural validity,we comfirmed Migraine PRO scale had good validity. Through the scale overall reaction degree and the item/domain reaction degree, we knew that its reaction degree is good. From three perspective of scale accept rate, completion rate and finish time, its feasibility was also proved to be relatively well.In the next step of research, based on the own characteristics of migraine, we will reference to the contents and evaluation method of the domestic PRO scale, improve the contents of migraine PRO scale, and using a variety of methods to evaluate performance evaluation.ConclusionMigraine curative effect evaluation system has not been fully set up. PRO scale fit for migraine to carry on the curative effect evaluation systemly. Our reaearch group has developed migraine PRO scale in2011. The content and structure of it is reasonable, and the performance evaluation of the preliminary results are reliable. The next step in the research can be improving the contents and making comprehensive evaluation based on the literature comparison.