Coronary Syndromes And Serum, Ykl 40 Mcp - 1 Level Correlation Studies

Objective:Use the study of the correlation of the different Chinese medicine syndrome types of Coronary heart disease (CHD) with the serum level of Monocyte chemotactic protein-l(MCP-l), Human cartilage glycoprotein-39(YKL-40), and the severity of coronary artery stenosis, and to discuss CHD syndromes objective quantitative index, provide an objective reliance for CHD syndrome differentiation, guide the syndrome differentiation and treatments.Methods:Choose124Cardiovascular Dept. inpatients, proved to be CHD patients by SCAG. The124CHD cases are divided into5groups, according to the Chinese Medicine Syndrome Diagnostic Standards, namely qi deficiency and yin deficiency syndrome with24cases (A), qi deficiency with blood stasis syndrome with24cases (B), blood stasis due to qi stagnation syndrome with25cases (C), phlegm turbidity obstructing heart vessel syndrome with26cases (D) and internal harassment of phlegm-heat syndrome with25cases (E). Choose another21cases healthy check-up as healthy control group.Use ELISA to assay the serum levels of MCP-1and YKL-40.Results:1Serum levels of MCP-1, YKL-40are significantly higher in CHD groups than the control group, indicating significant statistic difference (p<0.05).2The serum levels of MCP-1descend from three-vessel lesion group, via two-vessel lesion group, to one-vessel lesion group trend. And the serum levels of YKL-40descend from three-vessel lesion group, via one-vessel lesion group, to two-vessel lesion group.3According to the coronary Gensini integral, the serum levels of MCP-1descend from severe disease group, via moderate disease group, to mild disease group trend. The serum levels of YKL-40descend from severe disease group, via moderate disease group, to mild disease group trend.4In CHD groups, the serum levels of MCP-1descend as follows:C>D>E>B> A, and are higher in group C than other groups showing statistic difference (p<0.05). The serum levels of YKL-40descend as follows:B>E>D>A>C, and the serum levels of YKL-40in B are higher than other groups, showing statistic difference (p<0.05). 5The serum levels of MCP-1are higher in excess syndrome group than deficiency-excess complex syndrome group and deficiency syndrome group, showing statistic difference(p<0.05). The serum levels of YKL-40are higher in deficiency-excess complex syndrome group than excess syndrome group and deficiency syndrome group, showing statistic difference(p<0.05).6The results of the different Chinese medicine syndrome types of CHD and risk factors (including gender, age, smoking history, the coronary Gensini integral, serum level of MCP-1, serum level of YKL-40, coronary lesion vessels, etc.) binary logistic regression show:The rise of serum levels of YKL-40and the coronary Gensini integral, and the smoking history will increase the possibility of qi deficiency with blood stasis syndrome and decrease the possibility of the qi deficiency and yin deficiency syndrome and internal harassment of phlegm-heat syndrome. The rise of serum levels of MCP-1with no drinking history will increase possibility of the blood stasis due to qi stagnation syndrome.Conclusion:The study shows relationship between the serum levels of MCP-1and the blood stasis due to qi stagnation syndrome, and relationship between the serum level of YKL-40and the qi deficiency with blood stasis syndrome. The MCP-1and YKL-40can be promising objective indexes for CHD syndrome differentiation, and serve as the reference of CHD diagnosis and medication. There’s correlation of serum levels of MCP-1, YKL-40with the severity of coronary artery stenosis, and thus the two can be used as clinical test index for the severity of CHD.