B Raschig Left Temple Added In The Treatment Of Partial Onset Seizures Children Refractory Epilepsy Research

Objects: To evaluate efficacy and safety of Levetiratam(LEV) as an additive in the treatment of children with refractory partial seizures.Methods: Using open self controlled study,72patients with intractable partial epilepsy seizures (male40, female32, age of7month~15years) were the research object, the cases were collected in2009June-2011June, from Department of neurology outpatients and inpatients of Children’s Hospital of Shanxi Province, they were treated and followed up for6～24months, the curative effect and adverse reaction were observed.Results:①LEV as an additive in the treatment of children with refractory partial seizures achieved complete control in8cases (8/68), accounting for11.8%, effective in25cases (25/68), accounting for36.7%, the total efficiency was48.5%. Comparison seizure frequency before and after treatment, the difference was significant (P <0.05).②The LEV add-on therapy of simple partial seizures, the total efficiency was54.5%,therapy of complex partial seizures, the total efficiency was46.4%, partial seizures with secondary generalized seizures the total efficiency was48.3%, no significant differences between the three groups (P>0.05); LEV add-on therapy for less than4years age group, the total efficiency was48.6%, for more than4years old age group the total efficiency was48.4%, no significant differences between the two groups (P>0.05); LEV add-on therapy for patients less than3years course of treatment, the total efficiency was50%, duration of more than3years the total efficiency was46.7%, no significant differences between the two groups (P>0.05); LEV add-on therapy in children with abnormal cranial imaging,the total efficiency was47.2%, for those no abnormalities, the total efficiency of50%, no significant differences between the two groups (P>0.05).③The LEV add-on therapy in3,6,12and24months without attack rates were8.8%,14.7%,11.8%and11.8%.There are no statistical significance for the total efficiency among the group when treated for3month,6month,12month and24month.④For LEV add-on therapy, the effective dose was10-60mg.kg-l, the average effective dose was37mg.kg-l⑤For the LEV add-on therapy, the adverse effect rate was33.8%, including11cases of emotional abnormalities (aggressive behavior, grumpy, throwing things)(16.1%),6cases of fatigue, sleep over (8.8%);4cases of excitement, language, sleep time reduced (5.9%); skin rash in1cases (1.5%);1cases of diarrhea (1.5%). LEV dosage was reduced, and for some patients the adverse effect disappeared of their own after2～4weeks, no one stop the treatment. Allergy and blood, liver and kidney dysfunction and other adverse reactions were not found in the research.?The LEV add-on therapy in3,6,12and24months of retention rate was94.1%,51,5%,45.6%and44.1%. Conclusions: LEV add-on therapy in children with refractory partial seizures has exact effect. Seizure type, age, course of disease and if cranial imaging was abnormal has little effect on the curative effect. The efficacy is stable for long term treatment of LEV. LEV add-on therapy has good safety, higher retention rate, can be further used in clinical.