) Imide Covalent And Non Covalent Connection Cyclodextrin Design And Synthesis

Perylene derivatives are characterized by a strong absorption in visible region ofspectrum and exhibit a similarly strong fluorescence. Most perylene derivatives dyesdisplay emission above 500 nm that benefits by the improvement of the signal/noiseratio in biological system owing to the presence of high autofluorescence of livingcells. A lot of effort has been made to solve their water-solubility. With highfluorescence quantum yields (FQYs) and photostability, their potential as fluorescentdyes constitute fertile soil for research on fluorescent labelling.Chapter 1: The research and applications of perylene derivatives have beenreviewed, especially for the water soluble perylene derivatives. In addition, the basicproperties of cyclodextrins, self-assembly, the preparation and characterization ofinclusion compounds have been introduced. Based on the special structure ofcyclodextrins raise up the conditions to solve the water-soluble.Chapter 2: A method of two steps nitrification of perylene tetracarboxylicbisimides was developed to synthesize the 1,7-symmetrically and asymmetricallysubstituted PBIs with high yields under mild conditions. The second nitrification ofPBI taken place only at 7-position. The UV-vis and emission spectra of thederivatives in chloroform were discussed.Chapter 3: A series of water-soluble and high fluorescent perylene derivativeshave been synthesized based on the special structure of cyclodextrins. Through thespace effect of cyclodextrins to inhibition the accumulation of perylene plane, and usethe water-soluble of cyclodextrins to improve the perylene imide solubility. TheUV-vis and emission spectra of the derivatives in different ratio of DMF and H2Owere discussed.Chapter 4: In view of the special properties of cyclodextrins to self-assemblysupramolecular system. A series of azo-compounds with resistance structure havebeen synthesized. Azo-compouds as“axis”and cyclodextrins as“wheel”to formrotaxanes. The molecules through the inner chamber ofα-cyclodextrin by self-assembly, through the noncovalent bond formed the supramolecular system andby large groups to the seal to preventα-cyclodextrin slippage. Then connected toperylene derivatives to improve the water soluble of derivatives. In the process ofsynthesis rotaxanes, we tried different large groups to sealing side, the end that maybe due to the shaft is too short cause cyclodextrin not self-assembly intosupramolecular system.