The Effect Of Magnesium Isoglycyrrhizinate On The Liver Function Of The Patients With Primary Hepatic Carcinoma After Having Transcatheter Arterial Chemoembolization

Objective: To research the effect of transcatheter arterial chemoembo-lization (TACE) on liver function of the patients with primary hepaticcarcinoma (PHC); and to probe the protection mechanisms of MagnesiumIsoglycyrrhizinate on liver function of the patients with PHC post TACE.Methods:68patients with PHC who had TACE in Department ofGastroenterology of the Fourth Hospital of Hebei Medical University wereenrolled, aged39to84(61.1±11.7)years old;55males and13females;51belonging to Child-Pugh grade A,17belonging to grade B;7patients had portalvein tumor thrombosis;23patients had received simple iodine oil embolismand45patients had received the chemoembolization;. All patients whoaccorded with the diagnostic and inclusion criteria and had the complete andaccurate clinical data, were divided into two groups, group A (including35patients) were treated with Magnesium Isoglycyrrhizinate once a day, andgroup B (including33patients) with Polyene Phosphatidylcholine once a day.The rest of the therapeutic methods were same in two groups.The blood samples of the patients were separately collected one weekbefore and three days after TACE, and the liver function marker of alanineaminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin(TBIL), direct bilirubin (DBIL), alkaline phosphatase (ALP), glutamyltrans-peptiase (GGT), cholinesterase (CHE) were measured with automaticbiochemistry analyzer, and index of the liver function were analyzed with thestatistical software. P<0.05was considered statistically significant.Results:1As for the gender, age, portal vein tumor thrombosis, Child-Pughgrading system, treatment method, volume of lipidol, there were no statistical differences between groups A and B.2The liver function of the PHC patients pre-TACE and post TACEAs the result showed: compared with the liver function of patientspre-TACE, ALT [36.00(22.50) VS58.00(66.50), P=0.000], AST [43.00(29.50)VS65.00(58.00), P=0.000] and TBIL [15.45(9.88) VS21.30(15.02), P=0.000]were significantly increased in post TACE, which means liver cell membranewere damaged and metabolism of bilirubin disturbed. ALP [114.00(77.50) VS104.00(66.50), P=0.021] and CHE [154.00(89.25) VS108.50(86.75), P=0.000]were decreased, which means liver reserve function were affected by TACE. Asfor GGT [69.20(95.70) VS72.75(77.45), P=0.725], there was no statisticaldifference pre-TACE and post TACE.3The liver function of the patients with and without portal vein tumorthrombusAs for the ALT difference [27.28±32.43VS12.00(53.50), P=0.848], ASTdifference [31.00±42.59VS20.00(42.50),P=0.801],TBIL difference [7.83±5.56VS3.50(10.70), P=0.538], DBIL difference [5.15±5.89VS1.70(6.45),P=0.499], ALP difference [-1.14±37.59VS-9.09±33.31, P=0.557], GGTdifference [50989.93(36.40）VS-1.00(16.30), P=0.724], and CHE difference[-43.71±30.69VS-40.0(43.0), P=0.724], there was no statistical differencebetween the patients with and without portal vein tumor thrombus.4The liver function of chemoembolization group and simple iodine oilembolism groupAs for the ALT difference [18.00(81.00) VS9.00(37.00), P=0.102], ASTdifference [20.00(33.00) VS8.00(64.00), P=0.315], TBIL difference[5.50(12.10)VS3.56±8.07, P=0.133], DBIL difference [2.70(6.65)VS0.60(7.10), P=0.057], ALP difference [-8.77±32.80VS-7.30±35.73, P=0.866],GGT difference [0.40(16.10) VS1.20±32.11, P=0.902], and CHE difference[-40.00(40.00) VS-40.08±25.96, P=0.912], there was no statistical differencebetween chemoembolization group and simple iodine oil embolism group.5The different medicines effected on liver functionThe ALT difference in group A[9.00(37.00)] was lower than that in group B[27.00(103.00)](P=0.013). Which means the Magnesium Isoglycyrrhizinatewas superior to Polyene Phosphatidylcholine in protecting liver cells membrane.As for the difference of AST, TBIL, DBIL, ALP, GGT and CHE, there were nostatistical difference between groups A, and B (P>0.05).Conclusion:1The liver function were influenced by TACE, including liver cellmembrane were damaged, metabolism of bilirubin and bile duct functiondisturbed, and the liver reserve function reduced.2In our research, portal vein tumor thrombosis and chemotherapeuticsdidn’t play a role in effect on liver function with the PHC patients post TACE.3Both Magnesium Isoglycyrrhizinate and Polyene Phosphatidylcholinehad effect on the prevention of acute liver injury, and MagnesiumIsoglycyrrhizinate was superior to Polyene Phosphatidylcholine in protectingliver cell membrane, particularly in reducing ALT.