A Research On Plasma Adiponectin Concentrations And Ankle Brachial Index Correlated With Coronary Artery Di Sease

ObjectiveExplore plasma adiponectin, pulse wave velocity (PWV) changes in patients with coronary heart disease, further discussing both with coronary heart disease clinical classification of lesions and the degree of relationship, and to explore the relationship between them and clinical significance.MethodsThe study points coronary heart disease group and control group,65cases of coronary heart disease patients were selected from June2009-June2011during our heart medicine hospital patients, from2130healthy check-up in the control group were those with angiographically demonstrated coronary arteries and normal, no other causes of cardiovascular disease, hypertension, and diabetes without, the detection of the indexes in the normal range. The enzyme league immune method to detect the plasma adiponectin levels, arteriosclerosis detector PWV detection. According to the clinical classification of coronary heart disease, serious degree, PWV group value, this paper discusses the relations between the groups. Results165cases of coronary group and65cases of control group, the plasma adiponectin, x±s respectively is6.26±2.01,9.39±2.56, two groups was statistically significant difference (P<0.05);265cases of coronary heart disease, stable angina with31patients (47.69%), plasma adiponectin8.98±2.56, unstable angina has24cases, accounting for36.92%of the plasma adiponectin6.02±2.03, myocardial infarction has10patients (15.38%), plasma adiponectin4.56±1.99, each two groups t test, P value were less than0.05, the difference was statistically significant;365cases of coronary heart disease, coronary artery disease a21cases, accounting for32.30%, plasma adiponectin7.98±2.16, two artery disease25patients (36.46%), plasma adiponectin5.02±1.98, three teams of coronary artery disease (19cases),29.23%, plasma adiponectin3.56±2.33, each two groups t test, P value were less than0.05, the difference was statistically significant;465cases of coronary group and65cases of control group, and baPWV value is measured respectively15.27±1.70m/s,12.34±2.50m/s, two independent sample mean more, P<0.05), and the value difference was statistically significant;565cases of coronary heart disease, stable angina with31cases, accounting for47.69%, baPWV value14.01±2.16, unstable angina has24cases, accounting for36.92%of the value baPWV15.02±1.03, myocardial infarction has10cases, accounting for15.38%, baPWV value15.56±1.39such as table3.3shows, the two groups each t test, P value are greater than0.05, the difference was not statistically significant.665cases of coronary heart disease, a coronary artery pathological changes of21cases, accounting for32.30%, baPWV value of13.78±2.26, two artery disease25cases, accounting for36.46%, baPWV value15.20±2.58, three teams of coronary artery disease (19cases),29.23%, baPWV value17.46±2.43, each two groups t test, P value were less than0.05, the difference was statistically significant;7Patients with coronary heart disease baPWV average determination value of15.27±1.70, we provisions in14.00measured value (m/s) the following as low baPWV group,14.00(m/s) or more as a high baPWV group, with lower baPWV group of36cases, high baPWV group of29cases, low baPWV group and high baPWV plasma adiponectin leels are two independent sample mean more, P<0.05), and the value difference was statistically significant.Conclusion1Plasma adiponectin, PWV are associated to the coronary heart disease, coronary heart disease patients plasma adiponectin levels lower than those of the control group, PWV value coronary artery group the higher than those in the control group;2Plasma adiponectin and coronary heart disease clinical types and levels are linked to the disease, coronary artery disease with the degree and range of aggravating, plasma adiponectin concentration also gradually reduced, there is a relationship between the coronary heart disease and PWV lesions degree, along with the pathological changes of the degree increased when the PWVD is increasing3When PWV of the patients with coronary artery disease is increasing, but the plasma adiponectin levels drop, there is a coordinated role.