Effect Of Alcohol Combined With Hypothermia On Cerebral Resuscitation After Cardiac Arrest In Rabbits

Objective:Cardiopulmonary resuscitation (CPR) after successful survival patients still have40%～50%appear different degree of disorders of nervous functions. The purpose of this animal research to explore the protection of ethanol combined with hypothermia for brain protection after sudden cardiac arrest, provide new theory and new methods for the Cerebral Resuscitation after Cardiac Arrest(CA).Methods:Ventricular fibrillation (VF) was induced by the external electricity, after establish the rabbit model of the cardiopulmonary resuscitation, fourty adult rats were randomly divided into five groups(n=8):sham-operated group(group A)、control group(group B)、Hypothermia group(group C)%Intravenous of1.5g/kg alcohol group(group D、 Intravenous of1.5g/kg alcohol combined with hypothermia group(group E).Group B in the recovery after the success of the immediate intravenous saline. Group C in the recovery after the success of the immediate implementation of the local and head cold,put the ice in rabbit’s head, neck, quickly will tympanic membrane temperature drop to32℃-after34℃for maintaining body temperature to the end. Group D recovery after the success of the immediate intravenous1.5g/kg ethanol. Group E recovery after the success of the immediate implementation of the head and low temperature+intravenous1.5g/kg ethanol. In the process of the continuous monitoring mean arterial pressure(MAP). Recovery for up to24hours after the determination of the brain water content, blood S-100-b protein content, scope of cerebral infarction and neural function score (NFS).Results:Group B of the brain water content, serum s-100-B content, cerebral infarction area and neural function defect scale in the treatment group is significantly higher, group E each target detection is better than group C, D(P<0.05). Conclusions:Ethanol combined with hypothermia for sudden cardiac arrest Cerebral Resuscitation has a certain degree of protection.