A Retrospective Analysis Of Glioma In Clinical And Pathological Features

OBJECTICVE:To analysis the clinical and pathological characteristics of glioma cases in Qilu Hospital in nearly four years. Exploring the law of development of glioma in recent years as well as the possible causes and mechanisms of these changes, and to summary of main clinical and pathological characteristics of glioma. To provides reliable clinical information in its future of prevention and early diagnosis and treatment.METHODS:The medical records of986patients in Qilu Hospital of Shandong University from January2009to December2012, were reviewed.These patients suffered surgery because of glioma, and were confirmed by pathological diagnosis. The clinical characteristics of these patients were analyzed retrospectively, including the age structure, the sex ratio, the medical reasons, the location of tumor and the pathological diagnosis.RESULTS:1. From period2009to2012, the number of glioma patients showed increasing trend year by year. The total cases were205in2009,211in2010,243in2011,327in2012, respectively. The past four years the number of patients has increased year by year2. In male patients, the peak age of onset is between40-44. The average age is40.89±17.63. The median age is43.00. In female patients, Peak age of onset is between35～39age, its average age is41.26, the SD is17.99and the median age is43.00.3. In the children and adolescents, there was a decrease in the number of cases with the increasing ages of the male patients. In the female patients, there was no statistical relationship between the number of cases and ages4. The ratio of men to women was1.26to one. There was no significantly (p=0.175) statistical difference in the sex ratio each year from2009to2012.5. In general, patients have a variety of clinical presentation, including general symptoms and the local symptoms. The main complaint is headache, vomiting and papilledema, which are caused by increasing cranial pressure, accounting for90.87%.6. The total cases of frontal lobe gliomas is395(40.06%). The cases of temporal lobe gliomas is277(28.09%). Followed by these lobe is parietal lobe and cerebellar, respectively have118cases and89cases.it also accounting for11.97%and9.03%respectively, the occipital lobe has42case, accounting for4.26%. The leave of island lobe is least, and have28cases, accounting for2.84%. Other parts have92cases.7. The number of astrocytic tumors is most, it have742cases, accounting for75.25%. Oligodendroglial tumors have58cases, accounting for5.88%. Oligoastrocytic tumors have15cases, accounting for1.52%.Ependymal tumors have59cases, accounting for5.98%. Neuronal and mixed neuronal-glial tumos have38cases, accounting for3.85%.Choroid tumors have20cases, accounting for2.03%. Tumor of pineal region have5cases, accounting for0.51%. Embryonal tumors have49cases, accounting for4.97%CONCLUSIONS:1. In Our last4years, the number of glioma patients showed a grow trend, and to be emphasized, in every year the patients of astrocytic tumors account for a major proportion. With the following factors may be relevant:environmental changes, promotion of health concepts, hospital expangsion,etal.2. In our hospital, Adolescents and children less than20years old was another peak incidence, total cases is143, accounting for14.50%, male76cases, female67cases. There is a decreasing trend with increasing age of male patients, while during the female patients the relevance of age is not clear.3. From the results, there were clear gender differences in glioma patients. During each year, the number of male patients is more than female patients, males average age of onset is40.89. years old, the average age of onset for women:41.26years old, but there is no significant statistical differences in the sex ratio(χ2=3.49, p=0.175).4. Glioma patients have a variety of reasons for treatment, but the headaches, vomiting caused by elevated intracranial pressure is still the main clinical performance. glioma in different location can cause different severity of the clinical manifestations and symptoms.5. From the results, we can conclude that glioma has its predilection site, the first location is the frontal lobe, the second location is temporal lobe, the order of remain lobe is parietal and occipital lobe, minimum is insular lobe, and different types of gliomas are a different predilection site.