The Changes And Influential Factors Of Chemerin In Patients With Metabolic Syndrome

Objective: Metabolic syndrome is a group of the clinicalcharacteristics,which combined with series of metabolic diseasesseriously affects human health.The major clinical changes of metabolicsyndrome is the central obesity, diabetes or sugar damage, hypertension,dyslipidemia, and insulin resistance is common pathophysiological basis. Withthe change of modern lifestyle and the improvement of living standards, thePrevalence of metabolic syndrome is increasing fast. Multiple risk factors ofmetabolic syndrome are is not a simple sum, but synergistic exacerbat.Itsharm is the significant increase in the occurrence of diabetes and coronaryheart disease and other cardiovascular disease risk.It Has gradually becomethe major hazards that affect people’s health. Obesity, high blood pressure,high cholesterol, impaired glucose tolerance or type2diabetes are referred toas "death quartet”. Metabolic syndrome which one of the major cause ofdisability and human death, Has become a hot area of concern clinicians.With the research studies of adipose tissue for furthe, its exuberant endocrinefunction has gradually discovered. Adipocytokines play an important role inregulating whole body energy metabolism balance.Its Closely associated withinsulin resistance (IR), obesity, diabetes, coronary heart disease,hyperlipidemia, etc. Chemerin is a new adipokine discovered in2007,which isa protein secreted by the adipose tissue.Chemerin Can regulate adipocytedifferentiation and play an important role in the immune response,inflammation, lipid metabolism,and has a closely associated with insulinresistance. Domestic research has focused in animal studies for theRelationship with Metabolic Syndrome.However, the literature about thechange of plasma Chemerin levels in metabolic syndrome of the human bodystill less.This study was designed to clarify the changes of plasma Chemerin levels in patients with metabolic syndrome,and to investigate the relationshipamong plasma Chemerin levels and blood pressure, blood glucose, insulinresistance index, body mass index, blood lipids, uric acid, etc. According tothe role of the Chemerin in metabolic syndrome,we can provide a better guiedfor clinical work and provide a new target for future research anddevelopment of new drugs.Methods: Totally50cases with metabolic syndrome as experimentalgroup was selected from the cardiology and endocrinology department of TheSecond Affiliated Hospital of Hebei Medical University and24Normalpersons as control group. Diagnostic criteria for the metabolic syndrome isAccording to the definition of metabolic syndrome formulated byInternational Diabetes Federation in2005. All selected objects was measuredgeneral indicators and biochemical indicators: height, body mass, waistcircumference, hip circumference, fasting glucose, triglycerides, totalcholesterol, low-density lipoprotein cholesterol (LDL-C), high-densitylipoprotein cholesterol (HDL-C), fasting insulin and calculated their bodymass index, waist-hip ratio and insulin resistance index (HOMA-IR). PlasmaChemerin levels was measured by enzyme-linked immunosorbent assay(ELISA). The data was processed by using t test, Pearson correlation analysisand multiple linear regression analysis.Results:1、The blood pressure, waist circumference, BMI, waist-to-hipratio, total cholesterol, triglycerides, LDL-C, HOMA-IRof the The metabolicsyndrome group were higher than he control group (P <0.05).2、The plasma Chemerin levels was positively correlated with systolicblood pressure(r=0.489,P<0.05),diastolic blood pressure(r=0.216,P<0.05),triglycerides(r=0.517,P<0.05),LDL-C(r=0.286,P<0.05)， waistcircumference(r=0.213,P <0.05), BMI(r=0.517,P <0.05), waist-to-hip ratio,HOMA-IR(r=0.276,P <0.05)，hsCRP(r=0.145,P <0.05)，and negativelycorrelated with HDL(r=-0.212,P <0.05)。3、Chemerin as dependent variables and systolic blood pressure, diastolicblood pressure, triglycerides, waist circumference, BMI, waist-to-hip ratio, HOMA-IR etc.12possible influencing factors as independent variables,themultiple linear stepwise regressionanalysis draw a Regressionequation:Chemerin=1.468+7.216X2SBP-7.216XTG+3.590XBMI,,R=0.506.that iscan be considered as SBP,TG and BMI were the most important factors forplasma Chemerin levels.Conclusion:1、The plasma Chemerin level in Patients with metabolicsyndrome is higher than the normal control group. The Chemerin may be adamaging factor in the genesis and development of the metabolic syndrome.2、Plasma Chemerin level is positively correlated with blood pressure,lipids, fasting glucose, body mass index, insulin resistance index,high-sensitivity C-reactive protein, SBP,TG and BMI were the mostimportant factors for plasma Chemerin levels.